Bioorthogonal chemistry

For many years, our group has been developing techniques for the site-specific modification, labeling and tagging of nucleic acids. We were the first to introduce Diels-Alder reactions into nucleic acids chemistry, we worked with aldehyde-hydrazide chemistry, and currently we are using various types of „click“ reactions for site-specific multiple labeling of nucleic acids.

Other activities in this broader area are fluorescence-enhancing nucleic acids, and self-labeling RNA tags.

References:

1. Seelig & Jäschke, Tetrahedron Lett. 1997 (38) 7729.
   
2. Fiammengo et al., J. Am. Chem. Soc. 2005 (127) 9271.
   
3. Pfander et al., Nucleic Acids Res. 2007 (35) e25.
   
4. Schoch et al. J. Am. Chem. Soc. 2010 (132) 8846.
   
5. Wiesmayr & Jäschke, Bioorg. Med. Chem. 2011 (19) 1041.
   
6. Schoch et al., Chem. Commun. 2011 (47) 12536.