IPMB, Chemistry Department

Prof. Dr. Andres Jäschke
Room 309 [e-mail]

 
Adress:

Universität  Heidelberg
Institut für Pharmazie und Molekulare Biotechnologie
Im Neuenheimer Feld 364 D-69120 Heidelberg

 
Contact (Office 309)

Tel:+49 (0)6221 - 54 4851
Fax:+49(0)6221 - 54 6430
[e-mail]

 
Links

Molecular switches

One of the major goals in bioorganic research is to trigger molecular functions by external signals. These signals may be other molecules (effectors), light, or electric fields. We are working on ribozymes that are regulated by various principles. These systems may find applications in sensor development and nanotechnology.

 

Allosteric Activation

 

Light-induced regulation of ribozymes

There are many processes in nature that are controlled by light as for instance photosynthesis, light-triggered motion of microorganisms or sight. Common to all these natural systems is the use of chromophors to translate radiation into chemical signals. We want to apply the same principle to control the activity of ribozymes. As the tertiary structure plays a crucial role in RNA catalysis our strategy is to tether photochromic compounds to a ribozyme allowing to trigger a fully reversible conformational change. The alteration in structure should give rise to an active and an inactive conformer, with the possibility to switch easily by radiation between both states.

Light Switch

 

References:

  1. Helm et al. J. Am. Chem. Soc. 2005 (127) 10492.
  2. Amontov & Jäschke, Nucleic Acids Res. 2006 (34) 5032.
  3. Petermeier & Jäschke, Org. Biomol. Chem. 2009 (7) 288.
  4. Singer & Jäschke, J. Am. Chem. Soc. 2010 (132) 8372.
  5. Nierth et al., Chem. Commun. 2010 (46) 7975.
Letzte Änderung: 21.05.2014
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