IPMB, Chemistry Department

Prof. Dr. Andres Jäschke
Room 309 [e-mail]

 
Adress:

Universität  Heidelberg
Institut für Pharmazie und Molekulare Biotechnologie
Im Neuenheimer Feld 364 D-69120 Heidelberg

 
Contact (Office 309)

Tel:+49 (0)6221 - 54 4851
Fax:+49(0)6221 - 54 6430
[e-mail]

 
Links

PhD student positions

PhD student positions available in the Jäschke lab

Thank you for your interest in joining our group.
We are interested in bright, motivated students from all over the world. Our work on the borderline of chemistry and biology is highly interdisciplinary, and our team offers a scientifically challenging and stimulating environment for anyone interested in applying chemical approaches to biological questions and vice versa. At the moment, we have the following PhD projects available:

 

  • NAD-modified regulatory RNA – function and metabolism
  • New natural RNA modifications

 

You should have demonstrated excellence in your studies of biochemistry, biotechnology, or molecular biology. Essential traits for new lab members are genuine scientific interest, curiosity and the willingness to learn and apply techniques from different fields. You should already have some research experience, and at least two scientists (faculty level) should be able to assess your qualifications.

Positions:

These are paid university or project positions (0.5 E13). Starting date is to be negotiated. Heidelberg University is one of the top research universities in Germany, and the IPMB is a modern research institute working on cutting-edge projects in the life sciences.

Application details:

Informal inquiries are welcome (Prof. Dr. Andres Jäschke, jaeschke@uni-hd.de, +49 6221 54 48 53). Please submit your application only via the HBIGS international graduate school portal (www.hbigs.uni-heidelberg.de).

What happens after your application?

HBIGS will do a first screening, typically including a skype interview. If selected at this stage, I will get in touch with you and ask you to prepare a research proposal about a topic you would like to work on if accepted to this lab (not implying that you will actually be working on this, but it is an extremely good selection criterion). If I like what you submit, you will get invited to Heidelberg where you will have presentations and interviews both at the HBIGS selection committee and in my group.

NAD-modified regulatory RNA – function and metabolism.

We have recently discovered that certain regulatory RNAs (sRNAs) in E. coli are covalently linked to the ubiquitous redox cofactor NAD (nicotinamide adenine dinucleotide) in a way similar to a eukaryotic cap (Cahová et al., Nature 2015 (519) 374). First experiments indicate a role of this modification for the function and for the turnover of the sRNAs. This first description of a cap-like structure in prokaryotes provides an unprecedented connection between regulation and metabolism. Within this project we want to explore the scope and biological function(s) of this new RNA modification in different bacteria. We will conduct experiments to identify the capping / decapping machinery, isolate interaction partners of NAD-RNAs, investigate the dependence of NAD capping on growth phase, stress conditions, and redox state. We will also search for the occurrence of reduced NADH-RNAs. We will also search for NAD-modified RNAs in eukaryotic samples.

This project will involve a wide variety of methods from biochemistry, molecular biology and microbiology, as well as analysis of NGS data. We are looking for a PhD student with an M. Sc. in biochemistry, molecular biotechnology or related disciplines and hands-on experience in RNA or protein biochemistry and/or microbiology.

New natural RNA modifications.

We have recently discovered that certain regulatory RNAs (sRNAs) in E. coli are covalently linked to the ubiquitous redox cofactor NAD (nicotinamide adenine dinucleotide) in a way similar to a eukaryotic cap (Cahová et al., Nature 2015 (519) 374). First experiments indicate a role of this modification for the function and for the turnover of the sRNAs. This first description of a cap-like structure in prokaryotes provides an unprecedented connection between regulation and metabolism. 

NAD is only one of many biological molecules that carries a nucleotide that could lead to incorporation into RNA (Jäschke et al., Curr. Opin. Microbiol. 2016 (30) 44), such as Coenzyme A, FAD, SAM, UDP-sugars, or CDP-DAGs. Within this project we want to develop capture methods for RNAs carrying such modifications, identify the RNAs by high-throughput sequencing, and then study biogenesis and function in vivo. 

This project will involve a wide variety of methods from biochemistry and molecular biology, as well as analysis of NGS data. We are looking for a PhD student with an M. Sc. in biochemistry, molecular biotechnology or related disciplines and hands-on experience in RNA or protein biochemistry or chemical biology.

Letzte Änderung: 04.10.2017
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