Publications
2023
Shiraki Y., Mitsuma M., Takada R., Hata S., Kitamura A., Takada S., Kinjo M., Taru H.,
Müller U. C., Yamamoto T., Sobu Y., and Suzuki T., Gupton S; Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1; Monitoring Editor
Published Online:21 Sep 2023
https://www.molbiolcell.org/doi/10.1091/mbc.E22-10-0495
Schilling S., August A., Meleux M, Conradt C., Tremmel L. M., Teigler S., Adam V., Müller U. C., Koo Edward H., Kins S. & Eggert S.; APP family member dimeric complexes are formed predominantly in synaptic compartments; Cell & Bioscience volume 13, Article number: 141 (2023) Cite this article
https://www.cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01092-6
Lenz M., Eichler A., Kruse P., Galanis C., Kleidonas D., Andrieux G., Boerries M., Jedlicka P., Müller U., Deller T. and Vlachos A., The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses; Journal of Neuroscience 19 July 2023, 43 (29) 5290-5304; DOI: https://doi.org/10.1523/JNEUROSCI.1824-22.2023
https://www.jneurosci.org/content/43/29/5290
Danny Baltissen, Charlotte S. Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J. Buchholz, Martin Korte and Ulrike C. Müller; APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice; Front. Cell. Neurosci., 26 January 2023 Sec. Cellular Neurophysiology; Volume 17 - 2023
https://www.frontiersin.org/articles/10.3389/fncel.2023.1106176/full
2022
Susanne Erdinger, Irmgard Amrein, Michaela Back, Susann Ludewig, Martin Korte, Jakob von Engelhardt, David P. Wolfer and Ulrike C. Müller; Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory; Front. Mol. Neurosci., 28 October 2022 Sec. Brain Disease Mechanisms Volume 15 - 2022
https://www.frontiersin.org/articles/10.3389/fnmol.2022.1028836/full
Bold CS, Baltissen D, Ludewig S, Back MK, Just J, Kilian L, Erdinger S, Banicevic M, Rehra L, Almouhanna F, Nigri M, Wolfer DP, Spilger R, Rohr K, Kann O, Buchholz CJ, von Engelhardt J, Korte M, Müller UC. APPsα Rescues Tau-Induced Synaptic Pathology. J Neurosci. 2022 Jul 20;42(29):5782-5802. doi: 10.1523/JNEUROSCI.2200-21.2022. Epub 2022 Jun 6. PMID: 35667850; PMCID: PMC9302470.
https://www.jneurosci.org/content/42/29/5782.long
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12546
2021
https://www.life-science-alliance.org/content/4/11/e202000703
Naoto Oikawa, Marietta Fabiano, Ulrike C Müller, Jochen Walter Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition; Biochem Biophys Res Commun. 2021 Jul 16;570:137-142. PMID: 34280617 DOI: 10.1016/j.bbrc.2021.07.021
https://www.sciencedirect.com/science/article/pii/S0006291X21010585
Ludewig S, Herrmann U, Michaelsen-Preusse K, Metzdorf K, Just J, Bold C, Müller UC, Korte M. Amyloid-Beta Mediates Homeostatic Synaptic Plasticity; Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2011506118. doi: 10.1073/pnas.2011506118. PMID: 34172567
https://pubmed.ncbi.nlm.nih.gov/34172567/
Galanis C, Fellenz M, Becker D, Bold C, Lichtenthaler SF, Müller UC, Deller T, Vlachos A.; Amyloid-Beta Mediates Homeostatic Synaptic Plasticity; J Neurosci. 2021 Jun 16;41(24):5157-5172. doi: 10.1523/JNEUROSCI.1820-20.2021. Epub 2021 Apr 29. PMID: 33926999 F
https://pubmed.ncbi.nlm.nih.gov/33926999/
Vicky Steubler, Susanne Erdinger, Michaela K Back, Susann Ludewig, Dominique Fässler, Max Richter, Kang Han, Lutz Slomianka, Irmgard, Amrein, Jakob von Engelhardt, David P Wolfer, Martin Korte, Ulrike C Müller (2021) Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype EMBO J (2021):e107471
https://www.embopress.org/doi/full/10.15252/embj.2020107471
2020
Lauer AA, Mett J, Janitschke D, Thiel A, Stahlmann CP, Bachmann CM, Ritzmann F, Schrul B, Müller UC, Stein R, Riemenschneider M, Grimm HS, Hartmann T, Grimm MOW (2020) Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease. Aging Cell. 2020;19:e13264.
https://pubmed.ncbi.nlm.nih.gov/33128835/
Mehr A, Hick M, Ludewig S, Müller M, Herrmann U, von Engelhardt J, Wolfer DP, Korte M, Müller UC (2020) Lack of APP and APLP2 in GABAergic forebrain neurons impairs synaptic plasticity and cognition. Cereb Cortex 2020 Jun 1;30(7):4044-4063. doi:10.1093/cercor/bhaa025.
https://pubmed.ncbi.nlm.nih.gov/32219307/
Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B.M (2020) Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Mol Neurodegener Jan 8;15(1):3.
https://www.ncbi.nlm.nih.gov/pubmed/31915042
2019
Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C, Herms J.,Glia. 2019 May;67(5):985-998. doi: 10.1002/glia.23584. Epub 2019 Jan 22.
https://www.ncbi.nlm.nih.gov/pubmed/30667091
Oikawa, N, Müller UC, Walter, J (2019) GAMMA-SECRETASE INHIBITION INDUCES LIPID DROPLET ACCUMULATION VIA APP-CTF ACCUMULATION. Alzheimer's and Dementia 14(7):P1126
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2018.06.1509
2018
Herber J, Njavro J, Feederle R, Schepers U, Müller UC, Bräse S, Müller SA, Lichtenthaler SF. Mol Cell Proteomics. 2018 Aug;17(8):1487-1501. doi: 10.1074/mcp.RA118.000608. Epub 2018 May 1.
https://www.ncbi.nlm.nih.gov/pubmed/29716987
Barthet G, Jordà-Siquier T, Rumi-Masante J, Bernadou F, Müller U & Mulle C (2018) Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. Nature Communications 9(1):4780
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235831/
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC (2018) Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition. EMBO J. pii: e98335.
https://www.ncbi.nlm.nih.gov/pubmed/29661886
Herber J, Njavro J, Feederle R, Schepers U, Müller U, Bräse S, Müller S, Lichtenthaler SF. (2018) Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. Mol Cell Proteomics. pii: mcp.RA118.000608
https://www.ncbi.nlm.nih.gov/pubmed/29716987
2017
Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B (2017) Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO Mol Med. 8:1088-1099
https://www.ncbi.nlm.nih.gov/pubmed/?term=28588032
Müller UC, Deller T (2017) Editorial: The Physiological Functions of the APP Gene Family. Front Mol Neurosci. 10:334
https://www.ncbi.nlm.nih.gov/pubmed/?term=29109675
Han K, Müller UC, Hülsmann S (2017) Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network. Front Mol Neurosci. 10:189
https://www.ncbi.nlm.nih.gov/pubmed/?term=28690498
Laßek M, Weingarten J, Wegner M, Neupärtl M, Array TN, Harde E, Beckert B, Golghalyani V, Ackermann J, Koch I, Müller UC, Karas M, Acker-Palmer A, Volknandt W. (2017) APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones. Front Synaptic Neurosci. 9:1
https://www.ncbi.nlm.nih.gov/pubmed/?term=28163681
Mockett BG, Richter M, Abraham WC, Muller UC (2017) Therapeutic Potential of Secreted Amyloid Precursor Protein APPsalpha. Front Mol Neurosci 10:30.
https://www.ncbi.nlm.nih.gov/pubmed/28223920
Müller UC, Deller T, Korte M (2017) Not just amyloid: physiological functions of the amyloid precursor protein family. Nature reviews neuroscience in press.
https://www.ncbi.nlm.nih.gov/pubmed/28360418
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S (2017) APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission maintenance of dendritic spines and basal synaptic transmission. Journal of Neuroscience in press.
https://www.ncbi.nlm.nih.gov/pubmed/28450540
2016
Del Turco D, Paul MH, Schlaudraff J, Hick M, Endres K, Muller UC, Deller T (2016) Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci 9:134.
https://www.ncbi.nlm.nih.gov/pubmed/27965537
Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Muller UC (2016) Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model. Acta neuropathologica 131:247-266.
https://www.ncbi.nlm.nih.gov/pubmed/26538149
Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Muller UC, Draguhn A (2016) Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels. J Neurosci 36:8356-8371.
https://www.ncbi.nlm.nih.gov/pubmed/27511009
Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Muller U, Schweizer M, Saftig P, Brase S, Lichtenthaler SF (2016) Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife 5.
https://www.ncbi.nlm.nih.gov/pubmed/26802628
Lassek M, Weingarten J, Wegner M, Mueller BF, Rohmer M, Baeumlisberger D, Arrey TN, Hick M, Ackermann J, Acker-Palmer A, Koch I, Muller U, Karas M, Volknandt W (2016) APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone. PLoS Comput Biol 12:e1004832.
https://www.ncbi.nlm.nih.gov/pubmed/27092780
Strilic B, Yang L, Albarran-Juarez J, Wachsmuth L, Han K, Muller UC, Pasparakis M, Offermanns S (2016) Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature 536:215-218.
https://www.ncbi.nlm.nih.gov/pubmed/27487218
Zhang X, Zhong W, Brankack J, Weyer SW, Muller UC, Tort AB, Draguhn A (2016) Impaired theta-gamma coupling in APP-deficient mice. Sci Rep 6:21948.
https://www.ncbi.nlm.nih.gov/pubmed/26905287
Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Muller UC, Herms J (2016) Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO J 35.
https://www.ncbi.nlm.nih.gov/pubmed/27572463
2015
Grimm MO, Mett J, Stahlmann CP, Grosgen S, Haupenthal VJ, Blumel T, Hundsdorfer B, Zimmer VC, Mylonas NT, Tanila H, Muller U, Grimm HS, Hartmann T (2015) APP intracellular domain derived from amyloidogenic beta- and gamma-secretase cleavage regulates neprilysin expression. Frontiers in aging neuroscience 7:77.
https://www.ncbi.nlm.nih.gov/pubmed/26074811
Hick M, Herrmann U, Weyer SW, Mallm JP, Tschape JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Muller UC (2015) Acute function of secreted amyloid precursor protein fragment APPsalpha in synaptic plasticity. Acta neuropathologica 129:21-37.
https://www.ncbi.nlm.nih.gov/pubmed/25432317
Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Muller UC (2015) The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. J Neurosci 35:16018-16033.
https://www.ncbi.nlm.nih.gov/pubmed/26658856
Kundu A, Milosch N, Antonietti P, Baumkotter F, Zymny A, Muller UC, Kins S, Hajieva P, Behl C, Kogel D (2015) Modulation of BAG3 Expression and Proteasomal Activity by sAPPalpha Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol.
https://www.ncbi.nlm.nih.gov/pubmed/26526841
Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Muller UC, Di Luca M, De Strooper B, Bagni C (2015) Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome. Neuron 87:382-398.
https://www.ncbi.nlm.nih.gov/pubmed/26182420
Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, Muller UC, Deller T, Jedlicka P (2015) Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. J Comp Neurol 523:1717-1729.
https://www.ncbi.nlm.nih.gov/pubmed/25728909
Willem M et al. (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526:443-447.
https://www.ncbi.nlm.nih.gov/pubmed/26322584
2014
Grimm MO, Hundsdorfer B, Grosgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Patzold A, Zinser EG, Tanila H, Shen J, Muller U, Grimm HS, Hartmann T (2014) PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease. Cell Physiol Biochem 34:92-110.
https://www.ncbi.nlm.nih.gov/pubmed/24977484
Klevanski M, Saar M, Baumkotter F, Weyer SW, Kins S, Muller UC (2014) Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci 61C:201-210.
https://www.ncbi.nlm.nih.gov/pubmed/24998676
Lassek M, Weingarten J, Acker-Palmer A, Bajjalieh SM, Muller U, Volknandt W (2014) Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain. Curr Alzheimer Res 11:971-980.
https://www.ncbi.nlm.nih.gov/pubmed/25387333
Milosch N, Tanriover G, Kundu A, Rami A, Francois JC, Baumkotter F, Weyer SW, Samanta A, Jaschke A, Brod F, Buchholz CJ, Kins S, Behl C, Muller UC, Kogel D (2014) Holo-APP and G-protein-mediated signaling are required for sAPPalpha-induced activation of the Akt survival pathway. Cell death & disease 5:e1391.
https://www.ncbi.nlm.nih.gov/pubmed/25165877
Robinson A, Grosgen S, Mett J, Zimmer VC, Haupenthal VJ, Hundsdorfer B, Stahlmann CP, Slobodskoy Y, Muller UC, Hartmann T, Stein R, Grimm MO (2014) Upregulation of PGC-1alpha expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP. Aging cell 13:263-272.
https://www.ncbi.nlm.nih.gov/pubmed/24304563
Weyer SW, Zagrebelsky M, Herrmann U, Hick M, Ganss L, Gobbert J, Gruber M, Altmann C, Korte M, Deller T, Muller UC (2014) Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta neuropathologica communications 2:36.
https://www.ncbi.nlm.nih.gov/pubmed/24684730
2013 - 2007
Shariati, S. A. M., Lau, P., Hassan, B. A., Müller, U.C., Dotti, C. G., Strooper, B., and Annette Gärtner, A. (2013) APLP2 regulates neuronal stem cell differentiation during cortical development J. Cell Sci, 126:1268-7. doi: 10.1242/jcs.122440.
http://www.ncbi.nlm.nih.gov/pubmed/23345401
Caldwell JH, Klevanski M, Saar M, Müller UC (2013). Roles of the amyloid precursor protein family in the peripheral nervous system. Mech Dev. 2012 Nov 29. S0925-4773(12)00112-8. doi: 10.1016/j.mod.2012.11.001. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23201910
Müller, U. and Wild, K. (2013). Structure and Function of the APP Intracellular Domain in Health and Disease, Understanding Alzheimer's Disease, Prof. Inga Zerr (Ed.), ISBN: 978-953-51-1009-5, InTech, DOI: 10.5772/54543.
Kaufmann, M. R., Barth, S., Konietzko, U., Wu, B., Egger, S., Kunze, R., Marti, H. H., Hick, M., Müller, U., Camenisch, G., and Wenger, R. H. (2013) Dysregulation of Hypoxia-Inducible Factor by Presenilin/g-Secretase Loss-of-Function Mutations. J Neurosci 33: 1915–1926 .
http://www.ncbi.nlm.nih.gov/pubmed/?term=Kaufmann+Dysregulation+of+Hypoxia-Inducible
Marcus O. W. Grimm, M. O.W., Zinser, E. G., Grösgen, S., Hundsdörfer, B., Rothhaar, T. L., Burg, V. K., Kaestner, L., Bayer, T. A., Lipp, P., Müller, U., Grimm, H. S., and Hartmann, T. (2012). Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer’s Disease Pathology with Ganglioside Metabolism. PLoS ONE, 7 , e34095
http://www.ncbi.nlm.nih.gov/pubmed/?term=marcus+amyloid+precursor+Mediated+Regulation
Aydin, D., Weyer, S. W. and Müller, UC. (2012) Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 217, 423-434
http://link.springer.com/article/10.1007/s00221-011-2861-2
http://www.ncbi.nlm.nih.gov/pubmed/21931985
Müller, U. C., Pietrzik, C. U. and Deller, T. (2012) The physiological functions of the β-amyloid precursor protein APP. Exp Brain Res 217, 325-329.
http://link.springer.com/article/10.1007/s00221-012-3039-2
http://www.ncbi.nlm.nih.gov/pubmed/22349563
Müller, UC and Zheng, H. (2012). Physiological Functions of APP Family Proteins, CSH Persp. Med 2(2):a006288. doi:10.1101/cshperspect.a006288
http://www.ncbi.nlm.nih.gov/pubmed/22355794
Peter Jedlicka, P.,Owen, M., Vnencak, M., Jakob-A. Tschape, J.-A., Hick, M, Müller, U. C. and Deller, T. (2011) Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo. Exp Brain Res 2017, 441-447
http://link.springer.com/article/10.1007/s00221-011-2911-9
Nobles, R.D., Zhang C., Müller, U., Betz H., and McCall, M.A. (2012). Selective Glycine Receptr α2 Subunit Control of Crossover Inhibition Between the On and Off Retinal Pathways. J. Neurosci 32:3 321–3332.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Nobles+Selective+Glycine+Receptr+%CE%B12+Subunit
Weyer SA, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov MA, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. (2011). APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J, 30:2266-80.doi:10.1038/emboj.2011.119
Aydin D, Filippov MA, Tschäpe J-A, Gretz N, Prinz M, Eils R, Brors B, Müller UC. (2011). Comparative transcriptome profiling of Amyloid Precursor Protein family members in the adult cortex. BMC Genomics, 12:160.
Grimm, M. O.W., Grösgen, S., Rothhaar, T. L., Burg, V. K., Hundsörfer, B., Haupenthal, V. J., Friess, P., Müller, U., Fassbender, K., Riemenschneider, M., Grimm, H. S., and Hartmann, T. (2011) Intracellular APP domain (AICD) regulates serine-palmitoyl-CoA transferase (SPT) expression and is affected in Alzheimers disease. Int. Journal of Alzheimer´s Disease, 2011:695413.
Grimm, M.O.W., Kuchenbecker, J., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Burg, V. K., Friess, P., Müller, U., Grimm, H. S., Riemenschneider, M., and Tobias Hartmann, T. (2010). Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase (AGPS) by amyloid precursor protein (APP) processing and is affected in Alzheimer’s disease, J. Neurochem 116:916-25.
Anliker, B., Abel,T., Kneissl,S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C., Muench, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Müller, U. C., Hohenadl, C., Monyer, H., Cichutek, K., and Buchholz, C. J. (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods 7:929-35.
Manzke, T., Niebert, M., Koch, U. W., Caley, A., Vogelgesang, S.,Hülsmann,S., Ponimaskin, E., Müller, U., Smart,T. S., Harvey, R. J., and Richter, D. W. (2010). The Glycine Receptor α3 is a Molecular Switch Controlling Mammalian Breathing Rhythm. J. Clin Invest 20:4118-4128.
http://www.ncbi.nlm.nih.gov/pubmed/20978350
Copanaki, E., Chang, S., Vlachos, A., Tschäpe, J.-A., Müller, U. C., Kögel, D., Deller, T. (2010). sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci 44:386-393
Bergmans, B. A., Shariati, S. A. M., Habets, R. L.P., Verstreeken, P., Schoonjans, L., Müller, U., Dotti, C., DeStrooper, B. (2010). Neurons generated from APP/APLP1/APLP2 triple knockout neurons behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of AP in neuronal differentiation. Stem cells 28:399-406.
Mallm, J.-P., Jakob-Andreas Tschäpe, J. A., Hick, M., Filippov, M. A. and C. Müller, U. C. (2010). Generation of conditional null alleles for APP and APLP2. Genesis 48: 200 (DOI: 10.1002/dvg.20601)
Frank S, Copanaki E, Burbach G, Müller UC, Deller T (2009) Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett 453: 41-4.
Rajalu M, Müller U, Caley A, Harvey RJ, Poisbeau P (2009) Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor α3 subunit gene. Eur J Neurosci: 30, 2284
Szodorai A, KuanY-H, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-44.
Harvey, V. L., Caley, A., Müller, U., Robert J. Harvey, R. J. and Dickenson, A. H. (2009). A selective role for a3 subunit glycine receptors in inflammatory pain, Frontiers in Neurosci doi:10.3389/neuro.02.014.2009
Bach, P., Tschäpe, J.-A., Kopietz, F., Braun, G., Baade, J. K., Wiederhold, K.-H., Staufenbiel, M., Prinz|, M., Deller , T., Kalinke, U., J. Buchholz, C. J. and Müller, U. C. (2009). Vaccination with Aβ-displaying virus-like particles reduces soluble and insoluble cerebral A and lowers plaque burden in APP transgenic mice.
J. Immunology 182: 7613
Lourenço, F. C., Galvan,V., Fombonne, J., Corset, V., Llambi, F., Müller, U., , Bredesen, D. E., and Mehlen, P., Netrin-1 interacts with amyloid precursor protein and regulates amyloid-b production (2009). Cell Death and Diff, 16: 655-663 doi: 10.1038/cdd.2008.191
Tamboli, I., Prager, K., Thal, D. R., Thelen, K. M., Dewachter4, I., Pietrzik, C. U., St. George-Hyslop, P., Sisodia, S. S., Filippov, M., Müller, U., van Leuven, F., Lütjohann, D., and Walter, J. Loss of g-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (2008). J. Neuroscience, 28, 1207-12106
Gakhar-Koppole, N., Hundeshagen, P., Mandl, C., Alliquant, B., Müller, U., and Ciccolini, F. Neuronal activity promotes secretion of Amyloid Precursor Protein (sAPP) leading to neurite outgrowth in neural stem cells derived neurons via activation of MAPK pathway (2008). Eur J Neurosci, 28, 871–882.
Ring. S, Weyer, S., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M., Herms, J., Buchholz, C., Eckman, C. B., Martin Korte, M., Wolfer, D. P. and Müller, U. (2007) The secreted APPsα domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice J. Neuroscience, 27, 7817-7826
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