Prof. Ulrike Müller

Institute for Pharmacy and Molecular Biotechnology (IPMB)
Functional Genomics
University of Heidelberg
Im Neuenheimer Feld 364
69120 Heidelberg

Tel: +49-6221-546717 (office)
  +49 6221 54 5820 (secretary)
Fax: +49 6221 54 5830
email: E-Mail


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Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC (2018) Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition. EMBO J. pii: e98335.


Herber J, Njavro J, Feederle R, Schepers U, Müller U, Bräse S, Müller S, Lichtenthaler SF. (2018) Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. Mol Cell Proteomics. pii: mcp.RA118.000608


Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B (2017) Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO Mol Med. 8:1088-1099


Müller UC, Deller T (2017) Editorial: The Physiological Functions of the APP Gene Family. Front Mol Neurosci. 10:334

Han K, Müller UC, Hülsmann S (2017) Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network. Front Mol Neurosci. 10:189


Laßek M, Weingarten J, Wegner M, Neupärtl M, Array TN, Harde E, Beckert B, Golghalyani V, Ackermann J, Koch I, Müller UC, Karas M, Acker-Palmer A, Volknandt W. (2017) APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones. Front Synaptic Neurosci. 9:1


Mockett BG, Richter M, Abraham WC, Muller UC (2017) Therapeutic Potential of Secreted Amyloid Precursor Protein APPsalpha. Front Mol Neurosci 10:30.


Müller UC, Deller T, Korte M (2017) Not just amyloid: physiological functions of the amyloid precursor protein family. Nature reviews neuroscience in press.


Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S (2017) APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission maintenance of dendritic spines and basal synaptic transmission. Journal of Neuroscience in press.



Del Turco D, Paul MH, Schlaudraff J, Hick M, Endres K, Muller UC, Deller T (2016) Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci 9:134.


Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Muller UC (2016) Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model. Acta neuropathologica 131:247-266.


Hefter D, Kaiser M, Weyer SW, Papageorgiou IE, Both M, Kann O, Muller UC, Draguhn A (2016) Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels. J Neurosci 36:8356-8371.


Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Muller U, Schweizer M, Saftig P, Brase S, Lichtenthaler SF (2016) Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife 5.


Lassek M, Weingarten J, Wegner M, Mueller BF, Rohmer M, Baeumlisberger D, Arrey TN, Hick M, Ackermann J, Acker-Palmer A, Koch I, Muller U, Karas M, Volknandt W (2016) APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone. PLoS Comput Biol 12:e1004832.


Strilic B, Yang L, Albarran-Juarez J, Wachsmuth L, Han K, Muller UC, Pasparakis M, Offermanns S (2016) Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature 536:215-218.


Zhang X, Zhong W, Brankack J, Weyer SW, Muller UC, Tort AB, Draguhn A (2016) Impaired theta-gamma coupling in APP-deficient mice. Sci Rep 6:21948.


Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Muller UC, Herms J (2016) Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO J 35.



Grimm MO, Mett J, Stahlmann CP, Grosgen S, Haupenthal VJ, Blumel T, Hundsdorfer B, Zimmer VC, Mylonas NT, Tanila H, Muller U, Grimm HS, Hartmann T (2015) APP intracellular domain derived from amyloidogenic beta- and gamma-secretase cleavage regulates neprilysin expression. Frontiers in aging neuroscience 7:77.


Hick M, Herrmann U, Weyer SW, Mallm JP, Tschape JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Muller UC (2015) Acute function of secreted amyloid precursor protein fragment APPsalpha in synaptic plasticity. Acta neuropathologica 129:21-37.


Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Muller UC (2015) The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. J Neurosci 35:16018-16033.


Kundu A, Milosch N, Antonietti P, Baumkotter F, Zymny A, Muller UC, Kins S, Hajieva P, Behl C, Kogel D (2015) Modulation of BAG3 Expression and Proteasomal Activity by sAPPalpha Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol.


Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Muller UC, Di Luca M, De Strooper B, Bagni C (2015) Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome. Neuron 87:382-398.


Vnencak M, Paul MH, Hick M, Schwarzacher SW, Del Turco D, Muller UC, Deller T, Jedlicka P (2015) Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. J Comp Neurol 523:1717-1729.


Willem M et al. (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 526:443-447.



Grimm MO, Hundsdorfer B, Grosgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Patzold A, Zinser EG, Tanila H, Shen J, Muller U, Grimm HS, Hartmann T (2014) PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease. Cell Physiol Biochem 34:92-110.


Klevanski M, Saar M, Baumkotter F, Weyer SW, Kins S, Muller UC (2014) Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci 61C:201-210.


Lassek M, Weingarten J, Acker-Palmer A, Bajjalieh SM, Muller U, Volknandt W (2014) Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain. Curr Alzheimer Res 11:971-980.


Milosch N, Tanriover G, Kundu A, Rami A, Francois JC, Baumkotter F, Weyer SW, Samanta A, Jaschke A, Brod F, Buchholz CJ, Kins S, Behl C, Muller UC, Kogel D (2014) Holo-APP and G-protein-mediated signaling are required for sAPPalpha-induced activation of the Akt survival pathway. Cell death & disease 5:e1391.


Robinson A, Grosgen S, Mett J, Zimmer VC, Haupenthal VJ, Hundsdorfer B, Stahlmann CP, Slobodskoy Y, Muller UC, Hartmann T, Stein R, Grimm MO (2014) Upregulation of PGC-1alpha expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP. Aging cell 13:263-272.


Weyer SW, Zagrebelsky M, Herrmann U, Hick M, Ganss L, Gobbert J, Gruber M, Altmann C, Korte M, Deller T, Muller UC (2014) Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta neuropathologica communications 2:36.


2013 - 2007

Shariati, S. A. M., Lau, P., Hassan, B. A., Müller, U.C., Dotti, C. G., Strooper, B., and Annette Gärtner, A. (2013) APLP2 regulates neuronal stem cell differentiation during cortical development J. Cell Sci, 126:1268-7. doi: 10.1242/jcs.122440. Inhalt


Caldwell JH, Klevanski M, Saar M, Müller UC (2013). Roles of the amyloid precursor protein family in the peripheral nervous system. Mech Dev. 2012 Nov 29. S0925-4773(12)00112-8. doi: 10.1016/j.mod.2012.11.001. [Epub ahead of print] Inhalt


Müller, U. and Wild, K. (2013). Structure and Function of the APP Intracellular Domain in Health and Disease, Understanding Alzheimer's Disease, Prof. Inga Zerr (Ed.), ISBN: 978-953-51-1009-5, InTech, DOI: 10.5772/54543. Externer Inhalt


Kaufmann, M. R., Barth, S., Konietzko, U., Wu, B., Egger, S., Kunze, R., Marti, H. H., Hick, M., Müller, U., Camenisch, G., and Wenger, R. H. (2013) Dysregulation of Hypoxia-Inducible Factor by Presenilin/g-Secretase Loss-of-Function Mutations. J Neurosci 33: 1915–1926 . Inhalt


Marcus O. W. Grimm, M. O.W., Zinser, E. G., Grösgen, S., Hundsdörfer, B., Rothhaar, T. L., Burg, V. K., Kaestner, L., Bayer, T. A., Lipp, P., Müller, U., Grimm, H. S., and Hartmann, T. (2012). Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer’s Disease Pathology with Ganglioside Metabolism. PLoS ONE, 7 , e34095 Inhalt


Aydin, D., Weyer, S. W. and Müller, UC. (2012) Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res 217, 423-434 Inhalt Inhalt


MüllerExterner Inhalt, U. C., PietrzikExterner Inhalt, C. U. and DellerExterner Inhalt, T. (2012) The physiological functions of the β-amyloid precursor protein APPExterner Inhalt. Exp Brain Res 217, 325-329. Externer Inhalt Inhalt


Müller, UC and Zheng, H. (2012). Physiological Functions of APP Family Proteins, CSH Persp. Med 2(2):a006288. doi:10.1101/cshperspect.a006288 Inhalt


Peter Jedlicka, P.,Owen, M., Vnencak, M., Jakob-A. Tschape, J.-A., Hick, M, Müller, U. C. and Deller, T. (2011) Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo. Exp Brain Res 2017, 441-447 Inhalt Inhalt


Nobles, R.D., Zhang C., Müller, U., Betz H., and McCall, M.A. (2012). Selective Glycine Receptr α2 Subunit Control of Crossover Inhibition Between the On and Off Retinal Pathways. J. Neurosci 32:3 321–3332. Inhalt


Weyer SA, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov MA, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC. (2011). APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J, 30:2266-80.doi:10.1038/emboj.2011.119 Inhalt


Aydin D, Filippov MA, Tschäpe J-A, Gretz N, Prinz M, Eils R, Brors B, Müller UC. (2011). Comparative transcriptome profiling of Amyloid Precursor Protein family members in the adult cortex. BMC Genomics, 12:160. Inhalt


Grimm, M. O.W., Grösgen, S., Rothhaar, T. L., Burg, V. K., Hundsörfer, B., Haupenthal, V. J., Friess, P., Müller, U., Fassbender, K., Riemenschneider, M., Grimm, H. S., and Hartmann, T. (2011) Intracellular APP domain (AICD) regulates serine-palmitoyl-CoA transferase (SPT) expression and is affected in Alzheimers disease. Int. Journal of Alzheimer´s Disease, 2011:695413. Inhalt


Grimm, M.O.W., Kuchenbecker, J., Rothhaar, T. L., Grösgen, S., Hundsdörfer, B., Burg, V. K., Friess, P., Müller, U., Grimm, H. S., Riemenschneider, M., and Tobias Hartmann, T. (2010). Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase (AGPS) by amyloid precursor protein (APP) processing and is affected in Alzheimer’s disease, J. Neurochem 116:916-25. Inhalt


Anliker, B., Abel,T., Kneissl,S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C., Muench, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Müller, U. C., Hohenadl, C., Monyer, H., Cichutek, K., and Buchholz, C. J. (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods 7:929-35. Inhalt


Manzke, T., Niebert, M., Koch, U. W., Caley, A., Vogelgesang, S.,Hülsmann,S., Ponimaskin, E., Müller, U., Smart,T. S., Harvey, R. J., and Richter, D. W. (2010). The Glycine Receptor α3 is a Molecular Switch Controlling Mammalian Breathing Rhythm. J. Clin Invest 20:4118-4128. Externer Inhalt


Copanaki, E., Chang, S., Vlachos, A., Tschäpe, J.-A., Müller, U. C., Kögel, D., Deller, T. (2010). sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress. Mol Cell Neurosci 44:386-393 Inhalt


Bergmans, B. A., Shariati, S. A. M., Habets, R. L.P., Verstreeken, P., Schoonjans, L., Müller, U., Dotti, C., DeStrooper, B. (2010). Neurons generated from APP/APLP1/APLP2 triple knockout neurons behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of AP in neuronal differentiation. Stem cells 28:399-406. Inhalt


Mallm, J.-P., Jakob-Andreas Tschäpe, J. A., Hick, M., Filippov, M. A. and C. Müller, U. C. (2010). Generation of conditional null alleles for APP and APLP2. Genesis 48: 200 (DOI: 10.1002/dvg.20601) Inhalt


Frank S, Copanaki E, Burbach G, Müller UC, Deller T (2009) Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett 453: 41-4. Inhalt


Rajalu M, Müller U, Caley A, Harvey RJ, Poisbeau P (2009) Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor α3 subunit gene. Eur J Neurosci: 30, 2284 Inhalt


Szodorai A, KuanY-H, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-44. Inhalt


Harvey, V. L., Caley, A., Müller, U., Robert J. Harvey, R. J. and Dickenson, A. H. (2009). A selective role for a3 subunit glycine receptors in inflammatory pain, Frontiers in Neurosci doi:10.3389/neuro.02.014.2009 Inhalt


Bach, P., Tschäpe, J.-A., Kopietz, F., Braun, G., Baade, J. K., Wiederhold, K.-H., Staufenbiel, M., Prinz|, M., Deller , T., Kalinke, U., J. Buchholz, C. J. and Müller, U. C. (2009). Vaccination with Aβ-displaying virus-like particles reduces soluble and insoluble cerebral A and lowers plaque burden in APP transgenic mice.

J. Immunology 182: 7613 Inhalt


Lourenço, F. C., Galvan,V., Fombonne, J., Corset, V., Llambi, F., Müller, U., , Bredesen, D. E., and Mehlen, P., Netrin-1 interacts with amyloid precursor protein and regulates amyloid-b production (2009). Cell Death and Diff, 16: 655-663 doi: 10.1038/cdd.2008.191 Inhalt


Tamboli, I., Prager, K., Thal, D. R., Thelen, K. M., Dewachter4, I., Pietrzik, C. U., St. George-Hyslop, P., Sisodia, S. S., Filippov, M., Müller, U., van Leuven, F., Lütjohann, D., and Walter, J. Loss of g-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (2008). J. Neuroscience, 28, 1207-12106 Inhalt


Gakhar-Koppole, N., Hundeshagen, P., Mandl, C., Alliquant, B., Müller, U., and Ciccolini, F. Neuronal activity promotes secretion of Amyloid Precursor Protein (sAPP) leading to neurite outgrowth in neural stem cells derived neurons via activation of MAPK pathway (2008). Eur J Neurosci, 28, 871–882. Inhalt


Ring. S, Weyer, S., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M., Herms, J., Buchholz, C., Eckman, C. B., Martin Korte, M., Wolfer, D. P. and Müller, U. (2007) The secreted APPsα domain is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP deficient mice J. Neuroscience, 27, 7817-7826 Inhalt


Back S, Haas P, Tschape JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, and Kins S. (2007) Beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res, 85, 2580-2590. Inhalt


Older publications

2001 and older | 2001-2006 


Editor: E-Mail
Latest Revision: 2018-05-25
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