Publications

Kang H, Hasselbeck S, Taškova K, Wang N, Oosten LNV, Mrowka R, Utikal J, Andrade-Navarro MA, Wang J, Wölfl S, Cheng X.

2023

Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo.

Eur J Med Chem. 2023 Sep 5;257:115513. doi: 10.1016/j.ejmech.2023.115513. PMID: 37253308

Zhang JJ, Xu QJ, Schmidt C, Maaty MAAE, Song J, Yu C, Zhou J, Han K, Sun H, Casini A, Ott I, Wölfl S.

2023

Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) N-Heterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo.

J Med Chem. 2023 Mar 23;66(6):3995-4008. doi: 10.1021/acs.jmedchem.2c01925. PMID: 36898000

Blagojevic B, Almouhanna F, Poschet G, Wölfl S.

2022

Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1.

Cells. 2022 Nov 30;11(23):3863. doi: 10.3390/cells11233863. PMID: 36497120

Ghafoory S, Stengl C, Kopany S, Mayadag M, Mechtel N, Murphy B, Schattschneider S, Wilhelmi N, Wölfl S.

2022

diOxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation. Cells 2022; 11(23):3734. https://doi.org/10.3390/cells11233734

Alborzinia H, Flórez AF, Kreth S, Brückner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth J, Büttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wölfl S, Henrich KO, Höfer T, Trumpp A, Westermann F.

2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.

Nat Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. PMID: 35484422

Zuieva A, Can S, Boelke F, Reuter S, Schattscheider S, Töpfer E, Westphal A, Mrowka R, Wölfl S.

2022

Real-time monitoring of immediate drug response and adaptation upon repeated treatment in a microfluidic chip system.

Arch Toxicol. 2022 May;96(5):1483-1487. doi: 10.1007/s00204-022-03272-8. Epub 2022 Mar 19. PMID: 35304627

Zhou J, Dabiri Y, Gama-Brambila RA, Ghafoory S, Altinbay M, Mehrabi A, Golriz M, Blagojevic B, Reuter S, Han K, Seidel A, Đikić I, Wölfl S, Cheng X.

2022
pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.

Lederle M, Tric M, Roth T, Schütte L, Rattenholl A, Lütkemeyer D, Wölfl S, Werner T, Wiedemann P.

2021
Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality.

Almouhanna F, Blagojevic B, Can S, Ghanem A, Wölfl S.

2021
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells.

Ghanem A, Melzer AM, Zaal E, Neises L, Baltissen D, Matar O, Glennemeier-Marke H, Almouhanna F, Theobald J, Abu El Maaty MA, Berkers C, Wölfl S.

2021
Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis. Free Radic Biol Med. 2021 Feb 1;163:196-209. doi: 10.1016/j.freeradbiomed.2020.12.012. PMID: 33359260

Dropmann A, Dooley S, Dewidar B, Hammad S, Dediulia T, Werle J, Hartwig V, Ghafoory S, Wölfl S, Korhonen H, Janicot M, Wosikowski K, Itzel T, Teufel A, Schuppan D, Stojanovic A, Cerwenka A, Nittka S, Piiper A, Gaiser T, Beraza N, Milkiewicz M, Milkiewicz P, Brain JG, Jones DEJ, Weiss TS, Zanger UM, Ebert M, Meindl-Beinker NM.

2020
TGF-β2 silencing to target biliary-derived liver diseases.
Gut. 2020 Sep;69(9):1677-1690. doi: 10.1136/gutjnl-2019-319091. PMID: 31992593

Zhang JJ, Abu El Maaty MA, Hoffmeister H, Schmidt C, Muenzner JK, Schobert R, Wölfl S, Ott I.

2020
A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT-116 Colorectal Carcinoma Cells.
Angew Chem Int Ed Engl. 2020 Jun 12. doi: 10.1002/anie.202006212. PMID: 32529715

Nwosu ZC, Piorońska W, Battello N, Zimmer AD, Dewidar B, Han M, Pereira S, Blagojevic B, Castven D, Charlestin V, Holenya P, Lochead J, De La Torre C, Gretz N, Sajjakulnukit P, Zhang L, Ward MH, Marquardt JU, di Magliano MP, Lyssiotis CA, Sleeman J, Wölfl S, Ebert MP, Meyer C, Hofmann U, Dooley S.

2020
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.
EBioMedicine. 2020 Apr;54:102699. doi: 10.1016/j.ebiom.2020.102699. PMID: 32330875

Cheng X, Haeberle S, Shytaj IL, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN, Wölfl S.

2020
NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.
Commun Biol. 2020 Jan 3;3:10. doi: 10.1038/s42003-019-0716-8. PMID: 31909202

Dabiri Y, Abu El Maaty MA, Chan HY, Wölker J, Ott I, Wölfl S, Cheng X.

2019
p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.
Front Oncol. 2019 May 29;9:438. doi: 10.3389/fonc.2019.00438. PMID: 31231607

Theobald J, Abu El Maaty MA, Kusterer N, Wetterauer B, Wink M, Cheng X, Wölfl S.

2019
In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.
Rep. 2019 Mar 15;9(1):4616. doi: 10.1038/s41598-019-40851-9. PMID: 30874583

Dabiri Y, Schmid A, Theobald J, Blagojevic B, Streciwilk W, Ott I, Wölfl S, Cheng X.

2018
A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.
Int J Mol Sci. 2018 Dec 9;19(12). PMID: 30544880

Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Wölfl S, Lindemann RK, Reiling JH.

2018
Golgi stress mediates redox imbalance and ferroptosis in human cells.
Commun Biol. 2018 Nov 28;1:210. PMID: 30511023

Abu El Maaty MA, Dabiri Y, Almouhanna F, Blagojevic B, Theobald J, Büttner M, Wölfl S.

2018
Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics.
Cancer Metab. 2018 Aug 30;6:11. PMID: 30181873

Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S.

2018
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
J Exp Clin Cancer Res. 2018 Sep 3;37(1):211. PMID: 30176945

Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I.

2018
Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
Eur J Med Chem. 2018 Aug 5;156:148-161. PMID: 30006161

Abu El Maaty MA, Almouhanna F, Wölfl S.

2018
Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?
Int J Mol Sci. 2018 Mar 10;19(3). PMID: 29534438

Gaitantzi H, Meyer C, Rakoczy P, Thomas M, Wahl K, Wandrer F, Bantel H, Alborzinia H, Wölfl S, Ehnert S, Nüssler A, Bergheim I, Ciuclan L, Ebert M, Breitkopf-Heinlein K, Dooley S.

2018
Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.
Cell Death Dis. 2018 Jan 19;9(2):51. PMID: 29352207

Theobald J, Ghanem A, Wallisch P, Banaeiyan A, Andrade-Navarro M, Taškova K, Haltmeier M,  Kurtz A, Becker H, Reuter S, Mrowka R, Cheng X, Wölfl S.

2018

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites.

ACS Biomater. Sci. Eng., 2018, 4 (1), pp 78–89

Theobald J, Cheng X, Ghanem A, Gaitantzi H, Song G, Klipp E, Wodke J, Becker H, Mrowka R, Breitkopf-Heinlein K, Dooley S, Wölfl S.

2017

Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

Arch Toxicol. 2017 Dec 5. doi: 10.1007/s00204-017-2128-1. PMID: 29209748

Cheng X, Peuckert C, Wölfl S.

2017

Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

Sci Rep. 2017 Nov 13;7(1):15388. doi: 10.1038/s41598-017-15342-4. PMID: 29133922

Gaitantzi H, Hakenberg P, Theobald J, Heinlein H, Cai C, Loff S, Wölfl S, Ebert MP, Breitkopf-Heinlein K, Subotic U.

2017

Di(2-ethylhexyl) Phthalate and Its Role In Developing Cholestasis - An In Vitro Study On Different Liver Cell Types.

J Pediatr Gastroenterol Nutr. 2017 Oct 31. doi: 10.1097/MPG.0000000000001813. PMID: 29095348

Abu El Maaty MA, Wölfl S.

2017

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy.

Int J Mol Sci. 2017 Oct 19;18(10). pii: E2184. doi: 10.3390/ijms18102184. PMID: 29048387

Tric M, Lederle M, Neuner L, Dolgowjasow I, Wiedemann P, Wölfl S, Werner T.

2017

Optical biosensor optimized for continuous in-line glucose monitoring in animal cell culture.

Anal Bioanal Chem. 2017 Sep;409(24):5711-5721. doi: 10.1007/s00216-017-0511-7.

PMID: 28730310

Abu El Maaty MA, Alborzinia H, Khan SJ, Büttner M, Wölfl S.

2017

1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression.

Biochim Biophys Acta. 2017 Oct;1864(10):1618-1630. doi: 10.1016/j.bbamcr.2017.06.019. PMID: 28651973

Abu El Maaty MA, Strassburger W, Qaiser T, Dabiri Y, Wölfl S.

2017

Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

Mol Carcinog. 2017 Nov;56(11):2486-2498. doi: 10.1002/mc.22696. PMID: 28618116

Cheng X, Merz KH, Vatter S, Zeller J, Muehlbeyer S, Thommet A, Christ J, Wölfl S, Eisenbrand G.

2017

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.

J Med Chem. 2017 Jun 22;60(12):4949-4962. doi: 10.1021/acs.jmedchem.7b00324. PMID: 28557430

Göhring AR, Reuter S, Clement JH, Cheng X, Theobald J, Wölfl S, Mrowka R.

2017

Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis.

PLoS One. 2017 Apr 20;12(4):e0174912. doi: 10.1371/journal.pone.0174912. PMID: 28426762

Ghanem A, Kitanovic A, Holzwarth J, Wölfl S.

2017

Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress.

Microb Cell. 2017 Feb 1;4(2):52-63. doi: 10.15698/mic2017.02.557. PMID: 28357389

Banaeiyan AA, Theobald J, Paukštyte J, Wölfl S, Adiels CB, Goksör M.

2017

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform.

Biofabrication. 2017 Feb 3;9(1):015014. doi: 10.1088/1758-5090/9/1/015014.

PMID: 28155845

Abu El Maaty MA, Wölfl S.

2017

Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.

Nutrients. 2017 Jan 23;9(1). pii: E87. doi: 10.3390/nu9010087. PMID: 28124999

Bui VN, Nguyen TT, Mai CT, Bettarel Y, Hoang TY, Trinh TT, Truong NH, Chu HH, Nguyen VT, Nguyen HD, Wölfl S.

2017

Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes.

PLoS One. 2016 Dec 22;11(12):e0168721. doi: 10.1371/journal.pone.0168721. PMID: 28006013

Kim JY, Cheng X, Wölfl S.

2017

Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes.

Exp Cell Res. 2017 Jan 1;350(1):140-146. doi: 10.1016/j.yexcr.2016.11.015. PMID: 27884681

Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, Andersson L, Pettersson H, Wölfl S, Klein R, Oxburgh L, Kullander K.

2016

Multimodal Eph/Ephrin signaling controls several phases of urogenital development.

Kidney Int. 2016 Aug;90(2):373-388. doi: 10.1016/j.kint.2016.04.021. PMID: 27344203

Zhang JJ, Muenzner JK, Abu El Maaty MA, Karge B, Schobert R, Wölfl S, Ott I.

2016

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

Dalton Trans. 2016 Aug 16;45(33):13161-8. doi: 10.1039/c6dt02025a. PMID: 27334935

Nwosu ZC, Alborzinia H, Wölfl S, Dooley S, Liu Y.

2016

Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts.

Front Physiol. 2016 Jun 1;7:191. doi: 10.3389/fphys.2016.00191. PMID: 27313533

Alborzinia H, Shaikhkarami M, Hortschansky P, Wölfl S.

2016

BMP2 Transfer to Neighboring Cells and Activation of Signaling.

Traffic. 2016 Sep;17(9):1042-53. doi: 10.1111/tra.12420. PMID: 27306974

Kim JY, Cheng X, Alborzinia H, Wölfl S.

2016

Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes.

Biochem Biophys Res Commun. 2016 Apr 15;472(4):585-91. doi: 10.1016/j.bbrc.2016.03.031. PMID: 26972255

Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S.

2016

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.

Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. PMID: 26887594

Andermark V, Göke K, Kokoschka M, Abu El Maaty MA, Lum CT, Zou T, Sun RW, Aguiló E, Oehninger L, Rodríguez L, Bunjes H, Wölfl S, Che CM, Ott I.

2016

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

J Inorg Biochem. 2016 Jul;160:140-8. doi: 10.1016/j.jinorgbio.2015.12.020. PMID: 26850306

Belskaya NP, Lugovik KI, Bakulev VA, Bauer J, Kitanovic I, Holenya P, Zakhartsev M, Wölfl S.

2016

The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.

Eur J Med Chem. 2016 Jan 27;108:245-257. doi: 10.1016/j.ejmech.2015.11.011. PMID: 26686930

Oehninger L, Spreckelmeyer S, Holenya P, Meier SM, Can S, Alborzinia H, Schur J, Keppler BK, Wölfl S, Ott I.

2015

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling.

J Med Chem. 2015 Dec 24;58(24):9591-600. doi: 10.1021/acs.jmedchem.5b01159.

PMID: 26595649

Ramachandran SD, Schirmer K, Münst B, Heinz S, Ghafoory S, Wölfl S, Simon-Keller K, Marx A, Øie CI, Ebert MP, Walles H, Braspenning J, Breitkopf-Heinlein K.

2015

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells.

PLoS One. 2015 Oct 21;10(10):e0139345. doi: 10.1371/journal.pone.0139345.

PMID: 26488607

Bui VN, Nguyen TT, Bettarel Y, Nguyen TH, Pham TL, Hoang TY, Nguyen VT, Nghiem NM, Wölfl S. 

2015
Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter.

Int J Toxicol. 2015 Jan;34(1):31-43. doi: 10.1177/1091581814566870. PMID: 25691521

Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka R, Wölfl S.

2015
Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

J Med Chem. 2015 Aug 13;58(15):5742-50. doi: 10.1021/acs.jmedchem.5b00226. PMID: 26143659

Cheng X, Dimou E, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl S.

2015
Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers.

J Med Chem. 2015 Jun 25;58(12):4976-83. doi: 10.1021/acs.jmedchem.5b00144. PMID: 25898186

Ghafoory S, Mehrabi A, Hafezi M, Cheng X, Breitkopf-Heinlein K, Hick M, Huichalaf M, Herbel V, Saffari A, Wölfl S.

2015
Nuclear accumulation of CDH1 mRNA in hepatocellular carcinoma cells.

Oncogenesis. 2015 Jun 1;4:e152. doi: 10.1038/oncsis.2015.11.  PMID: 26029826

Gross A, Alborzinia H, Piantavigna S, Martin LL, Wölfl S, Metzler-Nolte N.

2015
Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates.

Metallomics. 2015 Feb;7(2):371-84. doi: 10.1039/c4mt00255e. PMID: 25608481

Guijarro C, Fuchs K, Bohrn U, Stütz E, Wölfl S.

2015
Simultaneous detection of multiple bioactive pollutants using a multiparametric biochip for water quality monitoring.

Biosens Bioelectron. 2015 Oct 15;72:71-9. doi: 10.1016/j.bios.2015.04.092. PMID: 25957833

Lochead J, Schessner J, Werner T, Wölfl S.

2015
Time-resolved cell culture assay analyser (TReCCA Analyser) for the analysis of on-line data: data integration--sensor correction--time-resolved IC50 determination.

PLoS One. 2015 Jun 25;10(6):e0131233. doi: 10.1371/journal.pone.0131233. eCollection 2015. PMID: 26110644

Cheng X, Holenya P, Can S, Alborzinia H, Rubbiani R, Ott I, Wölfl S.

2014
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

Mol Cancer. 2014 Sep 25;13:221. doi: 10.1186/1476-4598-13-221. PMID: 25253202

Cheng X, Merz KH, Vatter S, Christ J, Wölfl S, Eisenbrand G.

2014
7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells.

Bioorg Med Chem. 2014 Jan 1;22(1):247-55. doi: 10.1016/j.bmc.2013.11.031. PMID: 24326279

Heinonen AM, Rahman M, Dogbevia G, Jakobi H, Wölfl S, Sprengel R, Schwaninger M.

2014
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.

BMC Neurosci. 2014 Mar 11;15:38. doi: 10.1186/1471-2202-15-38. PMID: 24618040

Holenya P, Can S, Rubbiani R, Alborzinia H, Jünger A, Cheng X, Ott I, Wölfl S.

2014
Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

Metallomics. 2014 Sep;6(9):1591-601. doi: 10.1039/c4mt00075g. PMID: 24777153

Khatri P, Obernier K, Simeonova IK, Hellwig A, Hölzl-Wenig G, Mandl C, Scholl C, Wölfl S, Winkler J, Gaspar JA, Sachinidis A, Ciccolini F.

2014
Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

Sci Rep. 2014 Jan 22;4:3803. doi: 10.1038/srep03803. PMID: 24448162

Kitanovic I, Can S, Alborzinia H, Kitanovic A, Pierroz V, Leonidova A, Pinto A, Spingler B, Ferrari S, Molteni R, Steffen A, Metzler-Nolte N, Wölfl S, Gasser G.

2014
A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

Chemistry. 2014 Feb 24;20(9):2496-507. doi: 10.1002/chem.201304012. PMID: 24464824

Maschke M, Alborzinia H, Lieb M, Wölfl S, Metzler-Nolte N.

2014
Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production.

ChemMedChem. 2014 Jun;9(6):1188-94. doi: 10.1002/cmdc.201402001. PMID: 24838930

Meyer A, Oehninger L, Geldmacher Y, Alborzinia H, Wölfl S, Sheldrick WS, Ott I.

2014
Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.

ChemMedChem. 2014 Aug;9(8):1794-800. doi: 10.1002/cmdc.201402049. PMID: 24803348

Spincemaille P, Alborzinia H, Dekervel J, Windmolders P, van Pelt J, Cassiman D, Cheneval O, Craik DJ, Schur J, Ott I, Wölfl S, Cammue BP, Thevissen K.

2014
The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

Molecules. 2014 Sep 19;19(9):15088-102. doi: 10.3390/molecules190915088. PMID: 25244288

Stanke F, van Barneveld A, Hedtfeld S, Wölfl S, Becker T, Tümmler B.

2014
The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.

Eur J Hum Genet. 2014 May;22(5):660-6. doi: 10.1038/ejhg.2013.209.  PMID: 24105369

Ghafoory S, Breitkopf-Heinlein K, Li Q, Scholl C, Dooley S, Wölfl S.

2013

Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse.

PLoS One. 2013 Oct 17;8(10):e78262. doi: 10.1371/journal.pone.0078262. eCollection 2013. PMID: 24147127

Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Iikavets I, de Julio MK, Munker S, Marx A, Piiper A, Alonso EA, Gretz N, Gao C, Wölfl S, Dooley S, Breitkopf-Heinlein K.

Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X, Chen Q, Jiang Z, Feng H, Wolfl S.

2013
Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma.

Anal Cell Pathol (Amst). 2013;36(3-4):93-105. doi: 10.3233/ACP-130084. PMID: 24064399

Cheng X, Alborzinia H, Merz KH, Steinbeisser H, Mrowka R, Scholl C, Kitanovic I, Eisenbrand G, Wölfl S.

Oehninger L, Stefanopoulou M, Alborzinia H, Schur J, Ludewig S, Namikawa K, Muñoz-Castro A, Köster RW, Baumann K, Wölfl S, Sheldrick WS, Ott I.

2012
Evaluation of arene ruthenium(ii) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules.

Dalton Trans. 2012 Nov 14. [Epub ahead of print]  PMID: 23149817

Alborzinia H, Schmidt-Glenewinkel H, Ilkavets I, Breitkopf-Heinlein K, Cheng X, Hortschansky P, Dooley S, Wölfl S.

2012
Quantitative kinetic analysis of BMP2 uptake into cells and its modulation by BMP-antagonists.

J Cell Sci. 2012 Oct 17. [Epub ahead of print]  PMID: 23077176

Kitanovic A, Bonowski F, Heigwer F, Ruoff P, Kitanovic I, Ungewiss C, Wölfl S.

2012
Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5.

Front Oncol. 2012;2:118. doi: 10.3389/fonc.2012.00118. PMID: 23050242

Meyer A, Bagowski CP, Kokoschka M, Stefanopoulou M, Alborzinia H, Can S, Vlecken DH, Sheldrick WS, Wölfl S, Ott I.

2012
On the biological properties of alkynyl phosphine gold(I) complexes.

Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8895-9. PMID: 22848030

Scholl C, Weiβmüller K, Holenya P, Shaked-Rabi M, Tucker KL, Wölfl S.

2012
Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain.

BMC Genomics. 2012 Jul 2;13:298. PMID: 22748179

Holenya P, Heigwer F, Wölfl S.

2012
KOMA: ELISA-microarray calibration and data analysis based on kinetic signal amplification.

J Immunol Methods. 2012 Jun 29;380(1-2):10-5. PMID: 22484508

Ghafoory S, Breitkopf-Heinlein K, Li Q, Dzieran J, Scholl C, Dooley S, Wölfl S.

2012
A fast and efficient polymerase chain reaction-based method for the preparation of in situ hybridization probes.

Histopathology. 2012 Aug;61(2):306-13. PMID: 22458731

Nazif MA, Rubbiani R, Alborzinia H, Kitanovic I, Wölfl S, Ott I, Sheldrick WS.

2012
Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands.

Dalton Trans. 2012 May 14;41(18):5587-98. PMID: 22415580

Geldmacher Y, Splith K, Kitanovic I, Alborzinia H, Can S, Rubbiani R, Nazif MA, Wefelmeier P, Prokop A, Ott I, Wölfl S, Neundorf I, Sheldrick WS.

2012
Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts.

J Biol Inorg Chem. 2012 Apr;17(4):631-46. doi: 10.1007/s00775-012-0883-2. PMID: 22358334

Kasper C, Alborzinia H, Can S, Kitanovic I, Meyer A, Geldmacher Y, Oleszak M, Ott I, Wölfl S, Sheldrick WS.

2012
Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents.

J Inorg Biochem. 2012 Jan;106(1):126-33. PMID: 22115828

lbKöster S. D., Alborzinia H, Can S., Kitanovic I., Wölfl S. Rubbiani R., Ott I., Riesterer P., Prokop A., Merz K., Metzler-Nolte N.

A spontaneous gold(I)-azide alkyne cycloaddition reaction yields gold-peptide bioconjugates which overcome cisplatin resistance in a p53-mutant cancer cell line.

Chem. Sci. (2012), 3, 2062-2072.

Rubbiani R, Can S, Kitanovic I, Alborzinia H, Stefanopoulou M, Kokoschka M, Mönchgesang S, Sheldrick WS, Wölfl S, Ott I.

2011
Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

J Med Chem. 2011 Dec 22;54(24):8646-57. PMID: 22039997

Oehninger L, Alborzinia H, Ludewig S, Baumann K, Wölfl S, Ott I.

2011
From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

ChemMedChem. 2011 Dec 9;6(12):2142-5. PMID: 21901835

Alborzinia H, Can S, Holenya P, Scholl C, Lederer E, Kitanovic I, Wölfl S.

2011
Real-time monitoring of Cisplatin-induced cell death.

PLoS One. 2011;6(5):e19714. Epub 2011 May 16.PMID: 21603599

Holenya P, Kitanovic I, Heigwer F, Wölfl S.

2011
Microarray-based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis.

Proteomics. 2011 May;11(10):2129-33. Epub 2011 Apr 18.PMID: 21500346

Hackenberg F, Oehninger L, Alborzinia H, Can S, Kitanovic I, Geldmacher Y, Kokoschka M, Wölfl S, Ott I, Sheldrick WS.

2011
Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

J Inorg Biochem. 2011 Jul;105(7):991-9. PMID: 21569751

Geldmacher Y, Kitanovic I, Alborzinia H, Bergerhoff K, Rubbiani R, Wefelmeier P, Prokop A, gust R, Ott I, Wölfl S, Sheldrick WS.

2011
Cellular selectivity and biological impact of cytotoxic rhodium(III) and iridium(III) complexes containing methyl-substituted phenanthroline ligands.

ChemMedChem. 2011 Mar 7;6(3):429-39.
PMID: 21337523

Bieda R, Kitanovic I, Alborzinia H, Meyer A, Ott I, Wölfl S, Sheldrick WS.

2011
Antileukemic activity and cellular effects of rhodium (III) crown thiaether complexes
Biometals
Jan 28 PMID: 21274738

Lee, S.Y., Hille, A., Kitanovic, I., Jesse, P., Henze, G., Wölfl, S., Gust, R., Prokop, A.

2010
Fe (III) (salophene) CI, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells
Leuk. Res.
Dec 3. PMID: 21131047

Rubbiani, R., Kitanovic, I., Alborzinia, H., Can, S., Kitanovic, A., Onambele, L.A., Stefanopoulou, M., Geldmacher, Y., Sheldrick, W.S., Wolber, G., Prokop, A., Wölfl, S., Ott, I.

2010
Benzimidazol-2-ylidene gold(I) complexex are thioredoxin reductase inhibitors with multiple antitumor properties
J. Med. Chem
Dec. 23, 53 (24), 8608-18. PMID: 21082862

Lee, S.Y., Hille, A., Frias, C., Kater, B., Bonitzki, B., Wölfl, S., Scheffler, H., Prokop, A., Gust, R.

2010
Nill (3-OMe-salophene): a potent agent with antitumor activity
J. Med. Chem.
Aug 26, 53 (16), 6064-70 PMID: 20669965

Bonowski, F., Kitanovic, A., Ruoff, P., Holzwarth, J., Kitanovic, I., Bu,i V.N., Lederer, E., Wölfl, S.

2010
Computer controlled automated assay for comprehensive studies of enzyme kinetic parameters.
PLoS One
May 19, 5 (5): e10727 PMID: 20502716

Dransfeld, C.L., Alborzinia, H., Wölfl, S., Mahlknecht, U.

2010
SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability
In. J. Oncol.
Apr., 36 (4):955-60 PMID: 20198340

Tang, W., Ehrlich, I., Wolff, S.B., Michalski, A.M., Wölfl, S., Hasan, M.T., Lüth,i A., Sprenge,l R.:

2009
Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain circuits.
J. Neurosci.
Jul 8; 29 (27): 8621-9. PMID: 19587267

Kitanovic,  A., Walther,  T., Loret,  M.O., Holzwarth,  J., Kitanovic,  I., Bonowski,  F., Bui, N.V., Francois, J.M., Wölfl, S.

2009
Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium.
FEMS Yeast Res.
PMID: 19341380

Hille A., Ott I., Kitanovic A., Kitanovic I., Alborzinia H., Lederer E., Wölfl S., Metzler-Nolte N., Schäfer S., Sheldrick W.S., Bischof C., Schatzschneider U., Gust R.

Noor F., Kinscherf R., Bonaterra G.A., Walczak S., Wölfl S., Metzler-Nolte N.

Gaube, F., Wölfl, S., Pusch, L., Werner, U., Kroll, T.C., Schrenk, D., Hartmann, R.W., Hamburger, M.

Harlos, M., Ott, I., Gust, R., Alborzinia, H., Wölfl, S., Kromm, A., Sheldrick, W.S.

Kumar, V., Becker, T., Jansen, S., van Barneveld, A., Boztug, K., Wölfl, S., Tümmler, B., Stanke, F.

Schatzschneider, U., Niesel, J., Ott, I., Gust, R., Alborzinia, H., Wölfl, S.

Shakèd, M., Weissmüller, K., Svoboda, H., Hortschansky, P., Nishino, N., Wölfl, S., Tucker, K.L.

Steinert, S., Kroll, T.C., Taubert, I., Pusch, L., Hortschansky, P., Höffken, K., Wölfl, S., Clement, J.H.

2008
Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2
J Cancer Res Clin Oncol
Apr 30. PMID: 18446370

Veeriah, S., Miene, C., Habermann, N., Hofmann, T., Klenow, S., Sauer, J., Böhmer, F., Wölfl, S., Pool-Zobel, B.L.

Willaredt, M. A., Hasenpusch-Theil, K., Gardner, H. A., Kitanovic, I., Hirschfeld-Warneken, V. C., Gojak, C. P., Gorgas, K., Bradford, C. L., Spatz, J., Wölfl, S., Theil, T., Tucker, K.L.

Gaube, F., Wolfl, S., Pusch, L., Kroll, T.C., Hamburger, M.

Kitanovic, A., Wolfl, S.

Hoffmann, M., Pohlers, D., Koczan, D., Thiesen, H.J., Wolfl, S., Kinne, R.W.

Wölfl, S.

Clement JH, Raida M, Sanger J, Bicknell R, Liu J, Naumann A, Geyer A, Waldau A, Hortschansky P, Schmidt A, Hoffken K, Wolfl S, Harris AL.

Pool-Zobel BL, Selvaraju V, Sauer J, Kautenburger T, Kiefer J, Richter KK, Soom M, Wolfl S.

Kitanovic A, Nguyen M, Vogl G, Hartmann A, Gunther J, Wurzner R, Kunkel W, Wolfl S, Eck R.

Ritzka M, Stanke F, Jansen S, Gruber AD, Pusch L, Wolfl S, Veeze HJ, Halley DJ, Tummler B.

Beetz C, Hartmann A, Kiehntopf M, Wolfl S, Kalff R, Deufel T, Patt S.

Clement JH, Wolfl S

Wolfl S, Burchert A, Kroll TC.

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

Wölfl S, Dummer A, Pusch L, Pfalz M, Wang L, Clement JH, Leube I, Ehricht R

Herr A, Matthäi A, Rump A, Wölfl S, Schröck E

Burchert A, Wölfl S, Schmidt M, Brendel C, Dennecke B, Cai D, Odyvanova L, Lahaye T, Müller M, Berg T, Gschaidmeier H, Wittig B, Hehlmann R, Hochhaus A, Neubauer A

Preussat K, Beetz C, Schrey M, Kraft R, Wolfl S, Kalff R, Patt S

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

Kroll T, Odyvanova L, Clement JH, Platzer C, Naumann A, Marr N, Höffken K, Wölfl S

Kroll T, Wölfl S

Schrey M, Codina C, Kraft R, Beetz C, Kalff R, Wolfl S, Patt S

Wölfl S, Pachmann K, Höffken K, Clement JH

Wölfl S

Afanassiev V, Hanemann V, Wölfl S

Wölfl S, Diekmann S

Clement J, Marr N, Meißner A, Schwalbe M, Höffken K, Wölfl S

Afanassiev V, Sefton M, Anatachaiyong T, Barker G, Walmsley R, Wölfl S

Clement JH, Höffken K , Wölfl S

Fichter M, Wölfl S, Moore T, Zimmermann P

Schmidt MC, McCartney RR, Zhang X, Tillman TS, Solimeo H, Wölfl S, Almonte C , Watkins SC

Wölfl S, Martinez C, Majzoub J

Santorro R, Wölfl S , Saluz HP

Kroll T und Wölfl S

Famulok M, Jäschke A , Wölfl S

Ermantraut J, Wölfl S , Saluz HP

Hartung K, Frishman D, Hinnen A , Wölfl S

Berghöfer-Hochheimer Y, Zurek C, Wölfl S, Hemmerich P , Munder T

Kujau M , Wölfl S

Wölfl S, Kujau M, Siebert A , Wolters M

Kujau M , Wölfl S

Kujau M, Siebert A , Wölfl S

Ermantraut E, Wohlfart K, Wölfl S, Schulz T und Köhler M
1997
Microreactions on the surface of an oligonucleotide bearing chip.
Proceedings of 1st international Conference on Microreaction Technology, Springer Verlag, Heidelberg

Jacq C, …, Hanemann V, ..., Saluz HP, …, Wölfl S, et al

Wölfl S, Dorbic T, Wittig B, Rich A

Wölfl S, Martinez C, Rich A , Majzoub JA

Wölfl S, Hanemann V , Saluz HP