Dropmann A, Dooley S, Dewidar B, Hammad S, Dediulia T, Werle J, Hartwig V, Ghafoory S, Wölfl S, Korhonen H, Janicot M, Wosikowski K, Itzel T, Teufel A, Schuppan D, Stojanovic A, Cerwenka A, Nittka S, Piiper A, Gaiser T, Beraza N, Milkiewicz M, Milkiewicz P, Brain JG, Jones DEJ, Weiss TS, Zanger UM, Ebert M, Meindl-Beinker NM.

TGF-β2 silencing to target biliary-derived liver diseases.
Gut. 2020 Sep;69(9):1677-1690. doi: 10.1136/gutjnl-2019-319091. PMID: 31992593

Zhang JJ, Abu El Maaty MA, Hoffmeister H, Schmidt C, Muenzner JK, Schobert R, Wölfl S, Ott I.

A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT-116 Colorectal Carcinoma Cells.
Angew Chem Int Ed Engl. 2020 Jun 12. doi: 10.1002/anie.202006212. PMID: 32529715

Nwosu ZC, Piorońska W, Battello N, Zimmer AD, Dewidar B, Han M, Pereira S, Blagojevic B, Castven D, Charlestin V, Holenya P, Lochead J, De La Torre C, Gretz N, Sajjakulnukit P, Zhang L, Ward MH, Marquardt JU, di Magliano MP, Lyssiotis CA, Sleeman J, Wölfl S, Ebert MP, Meyer C, Hofmann U, Dooley S.

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.
EBioMedicine. 2020 Apr;54:102699. doi: 10.1016/j.ebiom.2020.102699. PMID: 32330875

Cheng X, Haeberle S, Shytaj IL, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN, Wölfl S.

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.
Commun Biol. 2020 Jan 3;3:10. doi: 10.1038/s42003-019-0716-8. PMID: 31909202

Dabiri Y, Abu El Maaty MA, Chan HY, Wölker J, Ott I, Wölfl S, Cheng X.

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.
Front Oncol. 2019 May 29;9:438. doi: 10.3389/fonc.2019.00438. PMID: 31231607

Theobald J, Abu El Maaty MA, Kusterer N, Wetterauer B, Wink M, Cheng X, Wölfl S.

In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.
Rep. 2019 Mar 15;9(1):4616. doi: 10.1038/s41598-019-40851-9. PMID: 30874583

Dabiri Y, Schmid A, Theobald J, Blagojevic B, Streciwilk W, Ott I, Wölfl S, Cheng X.

A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.
Int J Mol Sci. 2018 Dec 9;19(12). PMID: 30544880

Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Wölfl S, Lindemann RK, Reiling JH.

Golgi stress mediates redox imbalance and ferroptosis in human cells.
Commun Biol. 2018 Nov 28;1:210. PMID: 30511023

Abu El Maaty MA, Dabiri Y, Almouhanna F, Blagojevic B, Theobald J, Büttner M, Wölfl S.

Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics.
Cancer Metab. 2018 Aug 30;6:11. PMID: 30181873

Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S.

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
J Exp Clin Cancer Res. 2018 Sep 3;37(1):211. PMID: 30176945

Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I.

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
Eur J Med Chem. 2018 Aug 5;156:148-161. PMID: 30006161

Abu El Maaty MA, Almouhanna F, Wölfl S.

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein?
Int J Mol Sci. 2018 Mar 10;19(3). PMID: 29534438

Gaitantzi H, Meyer C, Rakoczy P, Thomas M, Wahl K, Wandrer F, Bantel H, Alborzinia H, Wölfl S, Ehnert S, Nüssler A, Bergheim I, Ciuclan L, Ebert M, Breitkopf-Heinlein K, Dooley S.

Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.
Cell Death Dis. 2018 Jan 19;9(2):51. PMID: 29352207

Theobald J, Ghanem A, Wallisch P, Banaeiyan A, Andrade-Navarro M, Taškova K, Haltmeier M,  Kurtz A, Becker H, Reuter S, Mrowka R, Cheng X, Wölfl S.


Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites.

ACS Biomater. Sci. Eng., 2018, 4 (1), pp 78–89

Theobald J, Cheng X, Ghanem A, Gaitantzi H, Song G, Klipp E, Wodke J, Becker H, Mrowka R, Breitkopf-Heinlein K, Dooley S, Wölfl S.


Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

Arch Toxicol. 2017 Dec 5. doi: 10.1007/s00204-017-2128-1. PMID: 29209748

Cheng X, Peuckert C, Wölfl S.


Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress.

Sci Rep. 2017 Nov 13;7(1):15388. doi: 10.1038/s41598-017-15342-4. PMID: 29133922

Gaitantzi H, Hakenberg P, Theobald J, Heinlein H, Cai C, Loff S, Wölfl S, Ebert MP, Breitkopf-Heinlein K, Subotic U.


Di(2-ethylhexyl) Phthalate and Its Role In Developing Cholestasis - An In Vitro Study On Different Liver Cell Types.

J Pediatr Gastroenterol Nutr. 2017 Oct 31. doi: 10.1097/MPG.0000000000001813. PMID: 29095348

Abu El Maaty MA, Wölfl S.


Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy.

Int J Mol Sci. 2017 Oct 19;18(10). pii: E2184. doi: 10.3390/ijms18102184. PMID: 29048387

Tric M, Lederle M, Neuner L, Dolgowjasow I, Wiedemann P, Wölfl S, Werner T.


Optical biosensor optimized for continuous in-line glucose monitoring in animal cell culture.

Anal Bioanal Chem. 2017 Sep;409(24):5711-5721. doi: 10.1007/s00216-017-0511-7.

PMID: 28730310

Abu El Maaty MA, Alborzinia H, Khan SJ, Büttner M, Wölfl S.


1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression.

Biochim Biophys Acta. 2017 Oct;1864(10):1618-1630. doi: 10.1016/j.bbamcr.2017.06.019. PMID: 28651973

Abu El Maaty MA, Strassburger W, Qaiser T, Dabiri Y, Wölfl S.


Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.

Mol Carcinog. 2017 Nov;56(11):2486-2498. doi: 10.1002/mc.22696. PMID: 28618116

Cheng X, Merz KH, Vatter S, Zeller J, Muehlbeyer S, Thommet A, Christ J, Wölfl S, Eisenbrand G.


Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.

J Med Chem. 2017 Jun 22;60(12):4949-4962. doi: 10.1021/acs.jmedchem.7b00324. PMID: 28557430

Göhring AR, Reuter S, Clement JH, Cheng X, Theobald J, Wölfl S, Mrowka R.


Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis.

PLoS One. 2017 Apr 20;12(4):e0174912. doi: 10.1371/journal.pone.0174912. PMID: 28426762

Ghanem A, Kitanovic A, Holzwarth J, Wölfl S.


Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress.

Microb Cell. 2017 Feb 1;4(2):52-63. doi: 10.15698/mic2017.02.557. PMID: 28357389

Banaeiyan AA, Theobald J, Paukštyte J, Wölfl S, Adiels CB, Goksör M.


Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform.

Biofabrication. 2017 Feb 3;9(1):015014. doi: 10.1088/1758-5090/9/1/015014.

PMID: 28155845

Abu El Maaty MA, Wölfl S.


Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.

Nutrients. 2017 Jan 23;9(1). pii: E87. doi: 10.3390/nu9010087. PMID: 28124999

Bui VN, Nguyen TT, Mai CT, Bettarel Y, Hoang TY, Trinh TT, Truong NH, Chu HH, Nguyen VT, Nguyen HD, Wölfl S.


Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes.

PLoS One. 2016 Dec 22;11(12):e0168721. doi: 10.1371/journal.pone.0168721. PMID: 28006013

Kim JY, Cheng X, Wölfl S.


Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes.

Exp Cell Res. 2017 Jan 1;350(1):140-146. doi: 10.1016/j.yexcr.2016.11.015. PMID: 27884681

Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, Andersson L, Pettersson H, Wölfl S, Klein R, Oxburgh L, Kullander K.


Multimodal Eph/Ephrin signaling controls several phases of urogenital development.

Kidney Int. 2016 Aug;90(2):373-388. doi: 10.1016/j.kint.2016.04.021. PMID: 27344203

Zhang JJ, Muenzner JK, Abu El Maaty MA, Karge B, Schobert R, Wölfl S, Ott I.


A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

Dalton Trans. 2016 Aug 16;45(33):13161-8. doi: 10.1039/c6dt02025a. PMID: 27334935

Nwosu ZC, Alborzinia H, Wölfl S, Dooley S, Liu Y.


Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts.

Front Physiol. 2016 Jun 1;7:191. doi: 10.3389/fphys.2016.00191. PMID: 27313533

Alborzinia H, Shaikhkarami M, Hortschansky P, Wölfl S.


BMP2 Transfer to Neighboring Cells and Activation of Signaling.

Traffic. 2016 Sep;17(9):1042-53. doi: 10.1111/tra.12420. PMID: 27306974

Kim JY, Cheng X, Alborzinia H, Wölfl S.


Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes.

Biochem Biophys Res Commun. 2016 Apr 15;472(4):585-91. doi: 10.1016/j.bbrc.2016.03.031. PMID: 26972255

Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S.


Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.

Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. PMID: 26887594

Andermark V, Göke K, Kokoschka M, Abu El Maaty MA, Lum CT, Zou T, Sun RW, Aguiló E, Oehninger L, Rodríguez L, Bunjes H, Wölfl S, Che CM, Ott I.


Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

J Inorg Biochem. 2016 Jul;160:140-8. doi: 10.1016/j.jinorgbio.2015.12.020. PMID: 26850306

Belskaya NP, Lugovik KI, Bakulev VA, Bauer J, Kitanovic I, Holenya P, Zakhartsev M, Wölfl S.


The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.

Eur J Med Chem. 2016 Jan 27;108:245-257. doi: 10.1016/j.ejmech.2015.11.011. PMID: 26686930

Oehninger L, Spreckelmeyer S, Holenya P, Meier SM, Can S, Alborzinia H, Schur J, Keppler BK, Wölfl S, Ott I.


Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling.

J Med Chem. 2015 Dec 24;58(24):9591-600. doi: 10.1021/acs.jmedchem.5b01159.

PMID: 26595649

Ramachandran SD, Schirmer K, Münst B, Heinz S, Ghafoory S, Wölfl S, Simon-Keller K, Marx A, Øie CI, Ebert MP, Walles H, Braspenning J, Breitkopf-Heinlein K.


In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells.

PLoS One. 2015 Oct 21;10(10):e0139345. doi: 10.1371/journal.pone.0139345.

PMID: 26488607

Bui VN, Nguyen TT, Bettarel Y, Nguyen TH, Pham TL, Hoang TY, Nguyen VT, Nghiem NM, Wölfl S. 

Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter.

Int J Toxicol. 2015 Jan;34(1):31-43. doi: 10.1177/1091581814566870. PMID: 25691521

Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka R, Wölfl S.

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4.

J Med Chem. 2015 Aug 13;58(15):5742-50. doi: 10.1021/acs.jmedchem.5b00226. PMID: 26143659

Cheng X, Dimou E, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl S.

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers.

J Med Chem. 2015 Jun 25;58(12):4976-83. doi: 10.1021/acs.jmedchem.5b00144. PMID: 25898186

Ghafoory S, Mehrabi A, Hafezi M, Cheng X, Breitkopf-Heinlein K, Hick M, Huichalaf M, Herbel V, Saffari A, Wölfl S.

Nuclear accumulation of CDH1 mRNA in hepatocellular carcinoma cells.

Oncogenesis. 2015 Jun 1;4:e152. doi: 10.1038/oncsis.2015.11.  PMID: 26029826

Gross A, Alborzinia H, Piantavigna S, Martin LL, Wölfl S, Metzler-Nolte N.

Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates.

Metallomics. 2015 Feb;7(2):371-84. doi: 10.1039/c4mt00255e. PMID: 25608481

Guijarro C, Fuchs K, Bohrn U, Stütz E, Wölfl S.

Simultaneous detection of multiple bioactive pollutants using a multiparametric biochip for water quality monitoring.

Biosens Bioelectron. 2015 Oct 15;72:71-9. doi: 10.1016/j.bios.2015.04.092. PMID: 25957833

Lochead J, Schessner J, Werner T, Wölfl S.

Time-resolved cell culture assay analyser (TReCCA Analyser) for the analysis of on-line data: data integration--sensor correction--time-resolved IC50 determination.

PLoS One. 2015 Jun 25;10(6):e0131233. doi: 10.1371/journal.pone.0131233. eCollection 2015. PMID: 26110644

Cheng X, Holenya P, Can S, Alborzinia H, Rubbiani R, Ott I, Wölfl S.

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

Mol Cancer. 2014 Sep 25;13:221. doi: 10.1186/1476-4598-13-221. PMID: 25253202

Cheng X, Merz KH, Vatter S, Christ J, Wölfl S, Eisenbrand G.

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells.

Bioorg Med Chem. 2014 Jan 1;22(1):247-55. doi: 10.1016/j.bmc.2013.11.031. PMID: 24326279

Heinonen AM, Rahman M, Dogbevia G, Jakobi H, Wölfl S, Sprengel R, Schwaninger M.

Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.

BMC Neurosci. 2014 Mar 11;15:38. doi: 10.1186/1471-2202-15-38. PMID: 24618040

Holenya P, Can S, Rubbiani R, Alborzinia H, Jünger A, Cheng X, Ott I, Wölfl S.

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

Metallomics. 2014 Sep;6(9):1591-601. doi: 10.1039/c4mt00075g. PMID: 24777153

Khatri P, Obernier K, Simeonova IK, Hellwig A, Hölzl-Wenig G, Mandl C, Scholl C, Wölfl S, Winkler J, Gaspar JA, Sachinidis A, Ciccolini F.

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

Sci Rep. 2014 Jan 22;4:3803. doi: 10.1038/srep03803. PMID: 24448162

Kitanovic I, Can S, Alborzinia H, Kitanovic A, Pierroz V, Leonidova A, Pinto A, Spingler B, Ferrari S, Molteni R, Steffen A, Metzler-Nolte N, Wölfl S, Gasser G.

A deadly organometallic luminescent probe: anticancer activity of a ReI bisquinoline complex.

Chemistry. 2014 Feb 24;20(9):2496-507. doi: 10.1002/chem.201304012. PMID: 24464824

Maschke M, Alborzinia H, Lieb M, Wölfl S, Metzler-Nolte N.

Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production.

ChemMedChem. 2014 Jun;9(6):1188-94. doi: 10.1002/cmdc.201402001. PMID: 24838930

Meyer A, Oehninger L, Geldmacher Y, Alborzinia H, Wölfl S, Sheldrick WS, Ott I.

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.

ChemMedChem. 2014 Aug;9(8):1794-800. doi: 10.1002/cmdc.201402049. PMID: 24803348

Spincemaille P, Alborzinia H, Dekervel J, Windmolders P, van Pelt J, Cassiman D, Cheneval O, Craik DJ, Schur J, Ott I, Wölfl S, Cammue BP, Thevissen K.

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

Molecules. 2014 Sep 19;19(9):15088-102. doi: 10.3390/molecules190915088. PMID: 25244288

Stanke F, van Barneveld A, Hedtfeld S, Wölfl S, Becker T, Tümmler B.

The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.

Eur J Hum Genet. 2014 May;22(5):660-6. doi: 10.1038/ejhg.2013.209.  PMID: 24105369

Ghafoory S, Breitkopf-Heinlein K, Li Q, Scholl C, Dooley S, Wölfl S.


Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse.

PLoS One. 2013 Oct 17;8(10):e78262. doi: 10.1371/journal.pone.0078262. eCollection 2013. PMID: 24147127

Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Iikavets I, de Julio MK, Munker S, Marx A, Piiper A, Alonso EA, Gretz N, Gao C, Wölfl S, Dooley S, Breitkopf-Heinlein K.

Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells.
Cancer Sci. 2013 Jan 3. doi: 10.1111/cas.12093. [Epub ahead of print]  PMID: 23281849

Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X, Chen Q, Jiang Z, Feng H, Wolfl S.

Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma.

Anal Cell Pathol (Amst). 2013;36(3-4):93-105. doi: 10.3233/ACP-130084. PMID: 24064399

Cheng X, Alborzinia H, Merz KH, Steinbeisser H, Mrowka R, Scholl C, Kitanovic I, Eisenbrand G, Wölfl S.

Indirubin derivatives modulate TGF?/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads.
Chem Biol. 2012 Nov 21;19(11):1423-36. doi: 10.1016/j.chembiol.2012.09.008.  PMID: 23177197


Oehninger L, Stefanopoulou M, Alborzinia H, Schur J, Ludewig S, Namikawa K, Muñoz-Castro A, Köster RW, Baumann K, Wölfl S, Sheldrick WS, Ott I.

Evaluation of arene ruthenium(ii) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules.

Dalton Trans. 2012 Nov 14. [Epub ahead of print]  PMID: 23149817

Alborzinia H, Schmidt-Glenewinkel H, Ilkavets I, Breitkopf-Heinlein K, Cheng X, Hortschansky P, Dooley S, Wölfl S.

Quantitative kinetic analysis of BMP2 uptake into cells and its modulation by BMP-antagonists.

J Cell Sci. 2012 Oct 17. [Epub ahead of print]  PMID: 23077176

Kitanovic A, Bonowski F, Heigwer F, Ruoff P, Kitanovic I, Ungewiss C, Wölfl S.

Acetic acid treatment in S. cerevisiae creates significant energy deficiency and nutrient starvation that is dependent on the activity of the mitochondrial transcriptional complex Hap2-3-4-5.

Front Oncol. 2012;2:118. doi: 10.3389/fonc.2012.00118. PMID: 23050242

Meyer A, Bagowski CP, Kokoschka M, Stefanopoulou M, Alborzinia H, Can S, Vlecken DH, Sheldrick WS, Wölfl S, Ott I.

On the biological properties of alkynyl phosphine gold(I) complexes.

Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8895-9. PMID: 22848030

Scholl C, Weiβmüller K, Holenya P, Shaked-Rabi M, Tucker KL, Wölfl S.

Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain.

BMC Genomics. 2012 Jul 2;13:298. PMID: 22748179

Holenya P, Heigwer F, Wölfl S.

KOMA: ELISA-microarray calibration and data analysis based on kinetic signal amplification.

J Immunol Methods. 2012 Jun 29;380(1-2):10-5. PMID: 22484508

Ghafoory S, Breitkopf-Heinlein K, Li Q, Dzieran J, Scholl C, Dooley S, Wölfl S.

A fast and efficient polymerase chain reaction-based method for the preparation of in situ hybridization probes.

Histopathology. 2012 Aug;61(2):306-13. PMID: 22458731

Nazif MA, Rubbiani R, Alborzinia H, Kitanovic I, Wölfl S, Ott I, Sheldrick WS.

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands.

Dalton Trans. 2012 May 14;41(18):5587-98. PMID: 22415580

Geldmacher Y, Splith K, Kitanovic I, Alborzinia H, Can S, Rubbiani R, Nazif MA, Wefelmeier P, Prokop A, Ott I, Wölfl S, Neundorf I, Sheldrick WS.

Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts.

J Biol Inorg Chem. 2012 Apr;17(4):631-46. doi: 10.1007/s00775-012-0883-2. PMID: 22358334

Kasper C, Alborzinia H, Can S, Kitanovic I, Meyer A, Geldmacher Y, Oleszak M, Ott I, Wölfl S, Sheldrick WS.

Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of organoruthenium anticancer agents.

J Inorg Biochem. 2012 Jan;106(1):126-33. PMID: 22115828

lbKöster S. D., Alborzinia H, Can S., Kitanovic I., Wölfl S. Rubbiani R., Ott I., Riesterer P., Prokop A., Merz K., Metzler-Nolte N.

A spontaneous gold(I)-azide alkyne cycloaddition reaction yields gold-peptide bioconjugates which overcome cisplatin resistance in a p53-mutant cancer cell line.

Chem. Sci. (2012), 3, 2062-2072.

Rubbiani R, Can S, Kitanovic I, Alborzinia H, Stefanopoulou M, Kokoschka M, Mönchgesang S, Sheldrick WS, Wölfl S, Ott I.

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

J Med Chem. 2011 Dec 22;54(24):8646-57. PMID: 22039997

Oehninger L, Alborzinia H, Ludewig S, Baumann K, Wölfl S, Ott I.

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

ChemMedChem. 2011 Dec 9;6(12):2142-5. PMID: 21901835

Alborzinia H, Can S, Holenya P, Scholl C, Lederer E, Kitanovic I, Wölfl S.

Real-time monitoring of Cisplatin-induced cell death.

PLoS One. 2011;6(5):e19714. Epub 2011 May 16.PMID: 21603599

Holenya P, Kitanovic I, Heigwer F, Wölfl S.

Microarray-based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis.

Proteomics. 2011 May;11(10):2129-33. Epub 2011 Apr 18.PMID: 21500346

Hackenberg F, Oehninger L, Alborzinia H, Can S, Kitanovic I, Geldmacher Y, Kokoschka M, Wölfl S, Ott I, Sheldrick WS.

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

J Inorg Biochem. 2011 Jul;105(7):991-9. PMID: 21569751

Geldmacher Y, Kitanovic I, Alborzinia H, Bergerhoff K, Rubbiani R, Wefelmeier P, Prokop A, gust R, Ott I, Wölfl S, Sheldrick WS.

Cellular selectivity and biological impact of cytotoxic rhodium(III) and iridium(III) complexes containing methyl-substituted phenanthroline ligands.

ChemMedChem. 2011 Mar 7;6(3):429-39.
PMID: 21337523

Bieda R, Kitanovic I, Alborzinia H, Meyer A, Ott I, Wölfl S, Sheldrick WS.

Antileukemic activity and cellular effects of rhodium (III) crown thiaether complexes
Jan 28 PMID: 21274738

Lee, S.Y., Hille, A., Kitanovic, I., Jesse, P., Henze, G., Wölfl, S., Gust, R., Prokop, A.

Fe (III) (salophene) CI, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells
Leuk. Res.
Dec 3. PMID: 21131047

Rubbiani, R., Kitanovic, I., Alborzinia, H., Can, S., Kitanovic, A., Onambele, L.A., Stefanopoulou, M., Geldmacher, Y., Sheldrick, W.S., Wolber, G., Prokop, A., Wölfl, S., Ott, I.

Benzimidazol-2-ylidene gold(I) complexex are thioredoxin reductase inhibitors with multiple antitumor properties
J. Med. Chem
Dec. 23, 53 (24), 8608-18. PMID: 21082862

Lee, S.Y., Hille, A., Frias, C., Kater, B., Bonitzki, B., Wölfl, S., Scheffler, H., Prokop, A., Gust, R.

Nill (3-OMe-salophene): a potent agent with antitumor activity
J. Med. Chem.
Aug 26, 53 (16), 6064-70 PMID: 20669965

Bonowski, F., Kitanovic, A., Ruoff, P., Holzwarth, J., Kitanovic, I., Bu,i V.N., Lederer, E., Wölfl, S.

Computer controlled automated assay for comprehensive studies of enzyme kinetic parameters.
PLoS One
May 19, 5 (5): e10727 PMID: 20502716

Dransfeld, C.L., Alborzinia, H., Wölfl, S., Mahlknecht, U.

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability
In. J. Oncol.
Apr., 36 (4):955-60 PMID: 20198340

Tang, W., Ehrlich, I., Wolff, S.B., Michalski, A.M., Wölfl, S., Hasan, M.T., Lüth,i A., Sprenge,l R.:

Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain circuits.
J. Neurosci.
Jul 8; 29 (27): 8621-9. PMID: 19587267

Kitanovic,  A., Walther,  T., Loret,  M.O., Holzwarth,  J., Kitanovic,  I., Bonowski,  F., Bui, N.V., Francois, J.M., Wölfl, S.

Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium.
FEMS Yeast Res.
PMID: 19341380

Hille A., Ott I., Kitanovic A., Kitanovic I., Alborzinia H., Lederer E., Wölfl S., Metzler-Nolte N., Schäfer S., Sheldrick W.S., Bischof C., Schatzschneider U., Gust R.

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties.
Inorg Chem.
PMID: 19259708

Noor F., Kinscherf R., Bonaterra G.A., Walczak S., Wölfl S., Metzler-Nolte N.

Enhanced cellular uptake and cytotoxicity studies of organometallic bioconjugates of the NLS peptide in Hep G2 cells.
10(3):493-502. PMID: 19115329

Gaube, F., Wölfl, S., Pusch, L., Werner, U., Kroll, T.C., Schrenk, D., Hartmann, R.W., Hamburger, M.

Effects of Leuzea carthamoides on Human Breast Adenocarcinoma MCF-7 Cells Determined by Gene Expression Profiling and Functional Assays
Planta Med.
74(14):1701-8. PMID: 18975255

Harlos, M., Ott, I., Gust, R., Alborzinia, H., Wölfl, S., Kromm, A., Sheldrick, W.S.

Synthesis, biological activity, and structure-activity relationships for potent cytotoxic rhodium(III) polypyridyl complexes
J Med Chem
51:3924-33. PMID: 18543901

Kumar, V., Becker, T., Jansen, S., van Barneveld, A., Boztug, K., Wölfl, S., Tümmler, B., Stanke, F.

Expression levels of FAS are regulated through an evolutionary conserved element in intron 2, which modulates cystic fibrosis disease severity
Genes Immun
9(8):689-96. PMID: 18685642

Schatzschneider, U., Niesel, J., Ott, I., Gust, R., Alborzinia, H., Wölfl, S.

Cellular uptake, cytotoxicity, and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 with N--N=bpy, phen, dpq, dppz, and dppn
3(7):1104-9. PMID: 18425738


Shakèd, M., Weissmüller, K., Svoboda, H., Hortschansky, P., Nishino, N., Wölfl, S., Tucker, K.L.

Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling
3(7):e2668. PMID: 18628975

Steinert, S., Kroll, T.C., Taubert, I., Pusch, L., Hortschansky, P., Höffken, K., Wölfl, S., Clement, J.H.

Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2
J Cancer Res Clin Oncol
Apr 30. PMID: 18446370

Veeriah, S., Miene, C., Habermann, N., Hofmann, T., Klenow, S., Sauer, J., Böhmer, F., Wölfl, S., Pool-Zobel, B.L.

Apple polyphenols modulate expression of selected genes related to toxicological defence and stress response in human colon adenoma cells
Int J Cancer
122(12):2647-55. PMID: 18351577

Willaredt, M. A., Hasenpusch-Theil, K., Gardner, H. A., Kitanovic, I., Hirschfeld-Warneken, V. C., Gojak, C. P., Gorgas, K., Bradford, C. L., Spatz, J., Wölfl, S., Theil, T., Tucker, K.L.

A crucial role for primary cilia in cortical morphogenesis.
J Neurosci
28(48):12887-900. PMID: 1903698

Gaube, F., Wolfl, S., Pusch, L., Kroll, T.C., Hamburger, M.

Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7.
BMC Pharmacol

Kitanovic, A., Wolfl, S.

Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae
Mutat Res.

Hoffmann, M., Pohlers, D., Koczan, D., Thiesen, H.J., Wolfl, S., Kinne, R.W.

Robust computational reconstitution - a new method for the comparative analysis of gene expression in tissues and isolated cell fractions
BMC Bioinformatics

Wölfl, S.

Chip Technologies, Basic Principles. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
Springer Verlag, Berlin Heidelberg
DOI 10.1007/3-540-29623-9

Clement JH, Raida M, Sanger J, Bicknell R, Liu J, Naumann A, Geyer A, Waldau A, Hortschansky P, Schmidt A, Hoffken K, Wolfl S, Harris AL.

Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells.
Int J Oncol.

Pool-Zobel BL, Selvaraju V, Sauer J, Kautenburger T, Kiefer J, Richter KK, Soom M, Wolfl S.

Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics.
Mar 3; [Epub ahead of print]

Kitanovic A, Nguyen M, Vogl G, Hartmann A, Gunther J, Wurzner R, Kunkel W, Wolfl S, Eck R.

Phosphatidylinositol 3-kinase VPS34 of Candida albicans is involved in filamentous growth, secretion of aspartic proteases, and intracellular detoxification.
FEMS Yeast Res.

Ritzka M, Stanke F, Jansen S, Gruber AD, Pusch L, Wolfl S, Veeze HJ, Halley DJ, Tummler B.

The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Hum Genet.

Beetz C, Hartmann A, Kiehntopf M, Wolfl S, Kalff R, Deufel T, Patt S.

Rapid generation of detailed loss of heterozygosity profiles for routine diagnosis of gliomas.
Clin Chem Lab Med
42: 595-601

Clement JH, Wolfl S

Bone morphogenetic proteins and cancer.
In Bone Morphogenetic Proteins: Regeneration of Bone and Beyond (S Vukicevic and KT Sampath, eds.) Birkhäuser Verlag (Basel, Switzerland)

Wolfl S, Burchert A, Kroll TC.

Monitoring therapy with gene expression profiling reveals physiological differences in drug action.
Current Pharmaceutic Design
10: 1959-68

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

The Chloroplast Genome of Nymphaea alba, Whole Genome Analyses and the Problem of Identifying the Most Basal Angiosperm.
Mol Biol Evol.
21: 1445-54

Wölfl S, Dummer A, Pusch L, Pfalz M, Wang L, Clement JH, Leube I, Ehricht R

Analyzing Proteins and Protein Modifications with ArrayTube™ Antibody Microarrays.
Protein Microarrays (M. Schena, ed), Jones and Bartlett Publishers (Sudbury, MA)

Herr A, Matthäi A, Rump A, Wölfl S, Schröck E

Das Chip-Zeitalter: Gegenwertiger Stand der Technik und Einsatzmöglichkeiten der ChipTechnologie in der Onkologie.
Der Onkologe
2004/10: 7-19

Burchert A, Wölfl S, Schmidt M, Brendel C, Dennecke B, Cai D, Odyvanova L, Lahaye T, Müller M, Berg T, Gschaidmeier H, Wittig B, Hehlmann R, Hochhaus A, Neubauer A

Interferon, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia.
101: 259-264.

Preussat K, Beetz C, Schrey M, Kraft R, Wolfl S, Kalff R, Patt S

Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas
Neurosci Lett.
346: 33-36.

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

Analysis of the Amborella trichopoda Chloroplast Genome Sequence Suggests That Amborella Is Not a Basal Angiosperm
Mol Biol Evol.
20: 1499-1505.

Goremykin VV, Hirsch-Ernst KI, Wolfl S, Hellwig FH

The chloroplast genome of tue „basal“ angiosperm Calycanthus fertilis - structural and phylogenetic analysis.
Plant Syst. Evol.
242: 119-135.

Kroll T, Odyvanova L, Clement JH, Platzer C, Naumann A, Marr N, Höffken K, Wölfl S

Molecular characterization of four breast cancer cell lines by expression profiling.
J. Cancer Research and Clinical Oncology
128: 125-134

Kroll T, Wölfl S

Ranking: a closer look on globalisation methods for normalisation of gene expression arrays
Nucleic Acids Research
30: e50.

Schrey M, Codina C, Kraft R, Beetz C, Kalff R, Wolfl S, Patt S

Molecular characterization of voltage-gated sodium channels in human gliomas
13: 2493-2498

Wölfl S, Pachmann K, Höffken K, Clement JH

Molekulares Screening
Der Onkologe
2002/8: 1098-1102

Wölfl S

Bio-Chip Technologien.
2000/4: 12-19

Afanassiev V, Hanemann V, Wölfl S

Preparation of DNA and protein micro arrays on glass slides coated with an agarose film.
Nucleic Acids Research
28: e66.

Wölfl S, Diekmann S

Aptamers (Editorial).
Reviews in Molecular Biotechnology
74: 3-4

Clement J, Marr N, Meißner A, Schwalbe M, Höffken K, Wölfl S

Expression pattern analysis reveals sequential induction of ID proteins in response to BMP-2 in the cancer model cell line MCF-7.
J. Cancer Research and Clinical Oncology
126: 271-279.

Afanassiev V, Sefton M, Anatachaiyong T, Barker G, Walmsley R, Wölfl S

Application of yeast cells transformed with GFP expression constructs containing the RAD54 or RNR2 promoter as a test for the genotoxic potential of chemical substnaces.
Mutation Res.
464: 297-308

Clement JH, Höffken K , Wölfl S

Molekularbiologische Methoden in der Tumordiagnostik.
1999/5: 867-876

Fichter M, Wölfl S, Moore T, Zimmermann P

Magnetische Aufreinigung von mRNA im Mikrotiterplattenformat.
7-8: 415-417

Schmidt MC, McCartney RR, Zhang X, Tillman TS, Solimeo H, Wölfl S, Almonte C , Watkins SC

Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae..
Molecular and Cellular Biology
19: 4561-4571

Wölfl S, Martinez C, Majzoub J

Inducible binding of CREB to the corticotropin-releasing hormone promoter in vivo
Molecular Endocrinology
13: 659-669

Santorro R, Wölfl S , Saluz HP

UV-laser induced Protein/DNA crosslinking reveals sequence variations of DNA-elements bound to c-Jun in vivo
Biochemical and Biophysical Research Communications
256: 68-74

Kroll T und Wölfl S

RNA-Biochemie (Trends 1998).
Nachr. Chem. Tech. Lab.
47: 178-180

Famulok M, Jäschke A , Wölfl S

Optimizing structure and function relationship of nucleic acid molecules.
In Microsystem Technology: a powerfull tool for biomolecular studies, eds. M. Köhler and H.P. Saluz, Birkhäuser Verlag, Basel

Ermantraut J, Wölfl S , Saluz HP

Generation of libraries by print technologies
In Microsystem Technology: a powerfull tool for biomolecular studies, eds. M. Köhler and H.P. Saluz, Birkhäuser Verlag, Basel

Hartung K, Frishman D, Hinnen A , Wölfl S

Single-read sequence tags of a limited number of genomic DNA fragments provide an inexpensive tool for comparative genome analysis
14: 1327-1332

Berghöfer-Hochheimer Y, Zurek C, Wölfl S, Hemmerich P , Munder T

L7 protein is a coregulator of vitamin D receptor - retinoid X receptor-mediated transactivation
J. Cell Biochem.
69: 1-12

Kujau M , Wölfl S

Intramolecular derivatization of 2'-amino-pyrimidine modified RNA with functional groups that is compatible with re-amplification
Nucleic Acids Res.
26: 1851-1853

Wölfl S, Kujau M, Siebert A , Wolters M

Oligonucleotide-Aptamers as Specific Targeting Devices in Diagnostics and Therapy. In Impact of Molecular Biology and New Technical Developments on Diagnostic Imaging,
Ernst Schering Research Foundation Workshops Vol. 22, eds. M. Schwaiger and W. Semmler, Springer Verlag, Heidelberg

Kujau M , Wölfl S

Efficient preparation of single-stranded DNA for in vitro selection.
Molecular Biotechnology
7: 333-335

Kujau M, Siebert A , Wölfl S

Design of leader sequences that improve the efficiency of the enzymatic synthesis of 2'-amino-pyrimidine RNA for in vitro selection.
J. Biochem. Biophys. Methods
35: 141-151

Ermantraut E, Wohlfart K, Wölfl S, Schulz T und Köhler M
Microreactions on the surface of an oligonucleotide bearing chip.
Proceedings of 1st international Conference on Microreaction Technology, Springer Verlag, Heidelberg

Jacq C, …, Hanemann V, ..., Saluz HP, …, Wölfl S, et al

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
387: 75-78

Wölfl S, Dorbic T, Wittig B, Rich A

Identification of processes that influence negative supercoiling in the human c-myc gene
Biochimica et Biophysica Acta
1352: 213-221

Wölfl S, Martinez C, Rich A , Majzoub JA

Transcription of the human CRH gene in NPLC cells is correlated with in vivo Z-DNA formation
Proc. Natl. Acad. Sci. USA
93: 3664-3668

Wölfl S, Hanemann V , Saluz HP

Analysis of a 26 756 bp segment from the left arm of yeast chromosome IV
12: 1549-1554


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Letzte Änderung: 02.10.2020