Medicinal Chemistry - Research
Current research activities:
- Viral proteases as drug targets (dengue, West Nile virus, Corona etc.)
- Combined phenotypic/target-oriented screening approaches, and their application in antiinfective drug discovery.
- Boronic acids in medicinal chemistry.
- New treatment paradigms for psychiatric and neurological disorders.
Methods include:
- Organic synthesis of ligands and inhibitors.
- Structure-based drug design, virtual screening.
- Protein biochemistry.
- Development of screening and assay methods.
- Molecular biology and genetic engineering.
- Crystallisation and (in collaboration) structure elucidation of protein-ligand complexes.
Equipment:
- Organic-synthetic laboratory with all standard equipment.
- Chemical analytics, including NMR facility with two spectrometers (300 and 500 MHz), etc.
- Other analytical methods such as MS, FTIR, UV-VIS.
- Microtiter plate readers.
- Laboratory for molecular biology with PCR, incubators, homogenizer, etc.
- Liquid chromatography (HPLC) for proteins and small molecules, various detection methods
- Graphical workstations with 3D-equipment. Various software packages.
- CHN Elemental analysis
- CD spectrophotometer
- NIR spectrometer
- Fermenter
- Microwave reactor
- Automated flash chromatography