Pharmaceutical Bioanalytics Research

Development of drugs

• Identification of new (cancer) drugs
• Target identification and target validation
• Organometallic compounds and small molecules derived from natural products

New (analytical) methods

• Biosensors (combination of cell-based assays and detection technology)
• (Rapid) analysis of gene expression and signal transduction
• Continuous online monitoring of cell metabolism (glycolysis, respiration)

Differentiation of cells

• Role of BMP signaling in cancer and development
•  Small molecules for reprogramming

Small molecules to facilitate cell reprogramming

• Targeted key pathways, e.g. Oct4 activation
   

Cell metabolism and cellular survival mechanisms

• Implications for drug treatment, toxicity and disease development

Cellular biosensors

• Development of biosensors for genotoxicity, cytotoxicity and environmental monitoring

Tools for the analysis of signal transduction networks

Microarrays for the analysis of proteins and regulatory modifications