SHIELD

WP1: Identification and characterization of virus-host recognition and entry mechanisms to identify novel targets

Lead: Universidade de Lisboa
This work package investigates how viruses recognize and enter host cells. By analyzing viral surface proteins and their interactions with receptors, antibodies, and nanobodies, WP1 aims to discover new targetable sites—especially those hidden in flexible or glycosylated regions—that could lead to broad-spectrum antiviral strategies.

WP2: Elucidation of glycosylation in host-virus interactions to understand, monitor and target viral entry and maturation

Lead: University of Copenhagen
WP2 focuses on the role of glycosylation in viral infection and immune evasion. Using innovative tools like a “Glyco-CRISPR” platform, researchers study how sugar molecules on viral and host proteins affect infection and how this process can be disrupted by targeted inhibitors.

WP3: Assay pipeline development and validation

Lead: Heidelberg University
To support the discovery and testing of new antiviral compounds, WP3 establishes a robust experimental pipeline. This includes detailed structural and biochemical analyses, as well as cellular and animal models that mimic viral infection to test how well new compounds block virus entry and replication.

WP4: Medicinal and bioorganic chemistry of viral entry and glycosylation

Lead: Radboud Universiteit
WP4 designs and develops small molecules and other compounds that interfere with viral entry and glycosylation processes. These efforts aim to demonstrate the druggability of the newly identified viral mechanisms, working hand-in-hand with the tools and targets from WP1–3.

WP5: Understanding the host immune response to virion glycosylation as a basis for novel vaccine development

Lead: University of Gdánsk
This work package explores how glycosylation on viral envelope proteins influences the immune system’s ability to recognize and fight infection. WP5’s findings will lay the groundwork for new vaccine strategies, particularly for viruses like Lassa and dengue.

WP6: Capacity Building, Communication, Dissemination and Exploitation

Lead: Heidelberg University
WP6 ensures that the knowledge and results generated by SHIELD are shared effectively—within the team, with the wider scientific community, and with policymakers and the public. It also builds future capacity by training young researchers and encouraging innovation and collaboration.

WP7: Project Management

Lead: Heidelberg University
WP7 is responsible for coordinating the project, ensuring that all activities stay on schedule and within budget. It supports communication across partners and guarantees compliance with Horizon Europe’s guidelines and reporting standards.